Fabrication and dual imaging properties of quantum dot/silica core-shell particles immobilized with gold nanoparticles

被引：3

作者：

Li, Ting-ting ^{[1
]}

Inose, Tomoya ^{[1
]}

Oikawa, Takahiro ^{[2
,3
]}

Tokunaga, Masayuki ^{[3
]}

Hatoyama, Keiichiro ^{[2
,3
]}

Nakashima, Kouichi ^{[1
]}

Kamei, Takashi ^{[2
]}

Gonda, Kohsuke ^{[3
]}

Kobayashi, Yoshio ^{[1
]}

机构：

[1] Ibaraki Univ, Grad Sch Sci & Engn, Dept Mat Sci & Engn, 4-12-1 Naka Narusawa Cho, Hitachi, Ibaraki 3168511, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Gastroenterol Surg, Sendai, Miyagi, Japan

[3] Tohoku Univ, Grad Sch Med, Dept Med Phys, Sendai, Miyagi, Japan

来源：

MATERIALS TECHNOLOGY | 2018年 / 33卷 / 11期

关键词：

Quantum dot; gold; silica-coating; core-shell; nanoparticle; fluorescence imaging; X-ray imaging; SURFACE-PLASMON RESONANCE; AU NANOPARTICLES; DRUG-DELIVERY; SILICA; DOTS; TUMOR; CELLS; GREEN;

D O I：

10.1080/10667857.2018.1502504

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The present work proposes a preparation method for core-shell nanoparticles composed of quantum dots (QDs), SiO2, large Au nanoparticles (Au-L), and small Au nanoparticles (Au-s). The QDs were silica-coated with a sol-gel method using tetraethyl orthosilicate (QD/SiO2). Au-L and Au-s were fabricated by reducing Au3+ ions with sodium citrate and tetrakis(hydroxymethyl)phosphonium chloride in water, respectively. Amino groups were introduced onto QD/SiO2 surface by using (3-aminopropyl)-triethoxysilane (QD/SiO2/NH2). Both Au-L and Au-s were immobilized on QD/SiO2/ NH2 by successively reacting Au-L and Au-s with QD/SiO2/NH2 (QD/SiO2/NH2/Au-L/Au-s). Surface modification of QD/SiO2/NH2/Au-L/Au-s was performed by using polyethylene glycol (PEG) with a thiol group (QD/SiO2/NH2/Au-L/Au-s/PEG). The QD/SiO2/NH2/Au-L/Au-s/PEG colloid solution could be clearly imaged via its fluorescence. Its computed tomography (CT) value per unit concentration of Au {M) was 1.2 x 10(4) HU/M. The QD/SiO2/NH2/Au-L/Au-S/PEGs were circulated in a mouse through blood vessels, and some of them became trapped and accumulated in the liver and spleen.

引用

页码：737 / 747

页数：11