Effects of chronic administration of nicotine on stress-induced changes in rats

被引：0
|
作者：
Kobayashi, Y [1 ]
Hattori, K [1 ]
Matsubara, K [1 ]
Gonda, T [1 ]
Tanabe, Y [1 ]
Ago, A [1 ]
Okunishi, H [1 ]
机构：
[1] Shimane Med Univ, Cent Res Labs, Izumo, Shimane 693, Japan
来源：
ADVANCES IN COMPARATIVE ENDOCRINOLOGY, TOMES 1 AND 2 | 1997年
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Effects of 2-week nicotine (Nic) administration on stress-induced changes in rats were studied using 4 groups: Nic+stress (Nic/st), untreated+stress (Un/st), Nic +control (Nic/con) and untreated+control (Un/con). The 17 hr-water-immersion stress induced gastric hemorrhage in Un/st but subtle lesion in Nic/st rats. Hypothalamic adrenaline(Ad) concentration was decreased in Un/st rats, but not in Nic/st or Nic/con rats. Serum ACTH concentration was increased in Un/st rats, but not in Nic/st or Nic/con groups. In contrast, the serum corticosterone, Ad and noradrenaline concentrations were increased in both Un/st and Nic/st rats. Vagotomy abolished the stress-induced gastric hemorrhage completely. Inhibitory effects of Nic on stress-induced gastric hemorrhage may be correlated with modification of hypothalamic Ad concentration. Vagus system plays an important role, while peripheral endocrine systems may contribute little to the inhibition.
引用
收藏
页码：1045 / 1049
页数：5
相关论文
共 50 条
  • [41] Effect of intracerebroventricular administration of vasopressin on stress-induced hyperthermia in rats
    Terlouw, EMC
    Kent, S
    Cremona, S
    Dantzer, R
    PHYSIOLOGY & BEHAVIOR, 1996, 60 (02) : 417 - 424
  • [42] Ventral hippocampal NMDA receptors mediate the effects of nicotine on stress-induced anxiety/exploratory behaviors in rats
    Farzamfard, Parinaz
    Rezayof, Ameneh
    Alijanpour, Sakineh
    NEUROSCIENCE LETTERS, 2022, 780
  • [43] Differential effects of chronic nicotine administration on markers of oxidative stress and cellular damage in male and female rats
    Hamid, Sumaiya Binte
    Sharif, Humaira
    Sajid, Faiza
    Bano, Samina
    PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 36 (03) : 811 - 818
  • [44] Nicotine has calming effects on stress-induced mood changes in females, but enhances aggressive mood in males
    File, SE
    Fluck, E
    Leahy, A
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2001, 4 (04): : 371 - 376
  • [45] Pathogenesis of nicotine treatment and its withdrawal on stress-induced gastric ulceration in rats
    Wong, D
    Koo, MWL
    Shin, VY
    Liu, ESL
    Cho, CH
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2002, 434 (1-2) : 81 - 86
  • [46] The effects of fluoxetine on oligodendrocytes in the hippocampus of chronic unpredictable stress-induced depressed model rats
    Wang, Jin
    Luo, Yanmin
    Tang, Jing
    Liang, Xin
    Huang, Chunxia
    Gao, Yuan
    Qi, Yingqiang
    Yang, Chunmao
    Chao, FengLei
    Zhang, Yang
    Tang, Yong
    JOURNAL OF COMPARATIVE NEUROLOGY, 2020, 528 (15) : 2583 - 2594
  • [47] Effects of Limonene on Chronic Restraint Stress-Induced Memory Impairment and Anxiety in Male Rats
    Bigdeli, Y.
    Asle-Rousta, M.
    Rahnema, M.
    NEUROPHYSIOLOGY, 2019, 51 (02) : 107 - 113
  • [48] Effects of acute and chronic treatment with fluoxetine on stress-induced hyperthermia in telemetered rats and mice
    Conley, Rachel K.
    Hutson, Peter H.
    EUROPEAN JOURNAL OF PHARMACOLOGY, 2007, 564 (1-3) : 138 - 145
  • [49] Effects of Limonene on Chronic Restraint Stress-Induced Memory Impairment and Anxiety in Male Rats
    Y. Bigdeli
    M. Asle-Rousta
    M. Rahnema
    Neurophysiology, 2019, 51 : 107 - 113
  • [50] Effects of testosterone and estradiol on stress-induced adrenal and hippocampal weight changes in female rats
    Sfikakis, Anastasia
    Pitychoutis, Pothitos M.
    Tsouma, Aikaterini
    Messari, Ioanna
    Papadopoulou-Daifoti, Zeta
    HORMONES-INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM, 2014, 13 (01): : 119 - 130
12345