Effects of chronic administration of nicotine on stress-induced changes in rats

被引：0
|
作者：
Kobayashi, Y [1 ]
Hattori, K [1 ]
Matsubara, K [1 ]
Gonda, T [1 ]
Tanabe, Y [1 ]
Ago, A [1 ]
Okunishi, H [1 ]
机构：
[1] Shimane Med Univ, Cent Res Labs, Izumo, Shimane 693, Japan
来源：
ADVANCES IN COMPARATIVE ENDOCRINOLOGY, TOMES 1 AND 2 | 1997年
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Effects of 2-week nicotine (Nic) administration on stress-induced changes in rats were studied using 4 groups: Nic+stress (Nic/st), untreated+stress (Un/st), Nic +control (Nic/con) and untreated+control (Un/con). The 17 hr-water-immersion stress induced gastric hemorrhage in Un/st but subtle lesion in Nic/st rats. Hypothalamic adrenaline(Ad) concentration was decreased in Un/st rats, but not in Nic/st or Nic/con rats. Serum ACTH concentration was increased in Un/st rats, but not in Nic/st or Nic/con groups. In contrast, the serum corticosterone, Ad and noradrenaline concentrations were increased in both Un/st and Nic/st rats. Vagotomy abolished the stress-induced gastric hemorrhage completely. Inhibitory effects of Nic on stress-induced gastric hemorrhage may be correlated with modification of hypothalamic Ad concentration. Vagus system plays an important role, while peripheral endocrine systems may contribute little to the inhibition.
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页码：1045 / 1049
页数：5
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