Interstitial pneumonia with autoimmune features in a patient with melanoma differentiation-associated gene 5 (MDA5) antibody

被引：0
|
作者：
Hong, Lih En [1 ,2 ]
Proudman, Susanna [1 ,2 ]
Limaye, Vidya [1 ,2 ]
机构：
[1] Royal Adelaide Hosp, Rheumatol Unit, Adelaide, SA, Australia
[2] Univ Adelaide, Discipline Med, Adelaide, SA, Australia
来源：
BMJ CASE REPORTS | 2020年 / 13卷 / 11期
关键词：
connective tissue disease; interstitial lung disease; radiology; lung function; immunology; LUNG-DISEASE; SPECTRUM;
D O I：
10.1136/bcr-2020-234946
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Melanoma differentiation-associated gene 5 (MDA5) antibody, also known as anti-CADM140 antibody is recognised to be associated with rapidly progressive interstitial lung disease, which can be fatal within 3months. It is also known to be associated with amyopathic dermatomyositis. We report a case of MDA5 antibody-associated interstitial pneumonia with autoimmune features, without cutaneous features of dermatomyositis, in a Sudanese patient with dual positive antibodies to Ro52. The patient notably had several features associated with poor prognosis, including age, high serum ferritin level, anti-Ro52 antibodies and progressive lung infiltrates during treatment.
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页数：4
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