Pharmaceutical-Oriented Iron-Catalyzed Ethoxylation of Aryl C(sp2)-H Bonds with Cobalt Co-Catalyst

被引：4

作者：

Zhang, Guofu ^{[1
]}

Zhu, Jianfei ^{[1
]}

Ding, Chengrong ^{[1
]}

机构：

[1] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Zhejiang, Peoples R China

来源：

CHEMISTRYSELECT | 2018年 / 3卷 / 34期

基金：

中国国家自然科学基金;

关键词：

Alkoxylation; cobalt co-catalyst; DMEDA; iron; Pharmaceutical-oriented; C-H BOND; MEDIATED DIRECT ARYLATION; CROSS-COUPLING REACTIONS; UNACTIVATED ARENES; ORTHO-ALKOXYLATION; ACTIVATION; FUNCTIONALIZATION; COMPLEXES; AMINATION; ALKENYLATION;

D O I：

10.1002/slct.201801881

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel and mild pharmaceutical-oriented iron-catalyzed ethoxylation of aryl C(sp(2))-H bonds with cobalt co-catalyst was successfully developed. The reaction occurs efficiently with broad substrate scope tolerance and high regioselectivity. It's the first example of C-H alkoxylation using inexpensive and low biotoxicity iron as a catalyst.

引用

页码：9803 / 9806

页数：4

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