In vitro activity of tedizolid and linezolid against multidrug-resistant Mycobacterium tuberculosis: a comparative study using microdilution broth assay and genomics

被引：7

作者：

Aono, Akio ^{[1
]}

Murase, Yoshiro ^{[1
]}

Chikamatsu, Kinuyo ^{[1
]}

Igarashi, Yuriko ^{[1
]}

Shimomura, Yoshiko ^{[1
]}

Hosoya, Makiko ^{[1
]}

Osugi, Asami ^{[1
]}

Morishige, Yuta ^{[1
]}

Takaki, Akiko ^{[1
]}

Yamada, Hiroyuki ^{[1
]}

Mitarai, Satoshi ^{[1
,2
]}

机构：

[1] Japan AntiTB Assoc, Res Inst TB, Dept Mycobacterium Reference & Res, Kiyose, Japan

[2] Nagasaki Univ, Basic Mycobacteriosis, Grad Sch Biomed Sci, Nagasaki, Japan

来源：

DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2022年 / 103卷 / 03期

关键词：

Tedizolid; Linezolid; Multidrug resistance; Mycobacterium tuberculosis; Minimum inhibitory concentration; Bone marrow suppression;

D O I：

10.1016/j.diagmicrobio.2022.115714

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The effects of tedizolid (TZD) against multidrug-resistant Mycobacterium tuberculosis isolates were investigated. This is possibly the first study to evaluate the MIC of TZD against Japanese Mycobacterium tuberculosis isolates. As TZD had a significantly lower MIC than LZD (P < 0.01), it was suggested to be a better, non-toxic alternative to LZD. (c) 2022 Elsevier Inc. All rights reserved.

引用

页数：3

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