Newly identified caveolin-1 mutation associated with heritable human pulmonary arterial hypertension mediates hyperproliferation via augmented calcium signaling

被引：0
|
作者：
Marsboom, Glenn [1 ]
Theriault, Kraig [1 ]
Debroy, Auditi [1 ]
Mao, Mao [1 ]
Baig, Saqib [1 ]
Tiruppathi, Chinnaswamy [1 ]
Bonini, Marcelo [1 ]
Rehman, Jalees [1 ]
Austin, Eric [2 ]
Malik, Asrar [1 ]
机构：
[1] Univ Illinois, Chicago, IL USA
[2] Vanderbilt Univ, Med Ctr, Nashville, TN USA
来源：
FASEB JOURNAL | 2014年 / 28卷 / 01期
关键词：
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
1089.10
引用
收藏
页数：1
相关论文
共 14 条
  • [1] A newly identified mutation in caveolin-1 associated with pulmonary arterial hypertension regulates the expression level of caveolin-1 and affects the stability of caveolin oligomers
    Han, B.
    Copeland, C.
    Drake, K.
    West, J.
    Austin, E.
    Loyd, J.
    Kenworthy, A.
    MOLECULAR BIOLOGY OF THE CELL, 2013, 24
  • [2] Characterization of a caveolin-1 mutation associated with both pulmonary arterial hypertension and congenital generalized lipodystrophy
    Han, Bing
    Copeland, Courtney A.
    Kawano, Yumeko
    Rosenzweig, Erika Berman
    Austin, Eric D.
    Shahmirzadi, Layla
    Tang, Sha
    Raghunathan, Krishnan
    Chung, Wendy K.
    Kenworthy, Anne K.
    TRAFFIC, 2016, 17 (12) : 1297 - 1312
  • [3] Expression of a Human Caveolin-1 Mutation in Mice Drives Inflammatory and Metabolic Defect-Associated Pulmonary Arterial Hypertension
    Rathinasabapathy, Anandharajan
    Copeland, Courtney
    Crabtree, Amber
    Carrier, Erica J.
    Moore, Christy
    Shay, Sheila
    Gladson, Santhi
    Austin, Eric D.
    Kenworthy, Anne K.
    Loyd, James E.
    Hemnes, Anna R.
    West, James D.
    FRONTIERS IN MEDICINE, 2020, 7
  • [4] Endothelial Cell Caveolin-1 Depletion Modulates TGF and Notch Signaling Associated with Pulmonary Arterial Hypertension
    Oliveira, Suellen DArc Santos
    Chen, Jiwang
    Castellon, Maricela
    Chernaya, Olga
    Colamonici, Oscar
    Bonini, Marcelo G.
    Machado, Roberto
    Minshall, Richard
    FASEB JOURNAL, 2018, 32 (01):
  • [5] Whole Exome Sequencing to Identify a Novel Gene (Caveolin-1) Associated With Human Pulmonary Arterial Hypertension
    Austin, Eric D.
    Ma, Lijiang
    LeDuc, Charles
    Rosenzweig, Erika Berman
    Borczuk, Alain
    Phillips, John A., III
    Palomero, Teresa
    Sumazin, Pavel
    Kim, Hyunjae R.
    Talati, Megha H.
    West, James
    Loyd, James E.
    Chung, Wendy K.
    CIRCULATION-CARDIOVASCULAR GENETICS, 2012, 5 (03) : 336 - 343
  • [6] Caveolin-1 associated with severe (pediatric-onset) presentation of pulmonary arterial hypertension
    Farrell, Rachel
    Colglazier, Elizabeth
    Parker, Claire
    Stevens, Leah
    Austin, Eric D.
    Fineman, Jeffrey R.
    PULMONARY CIRCULATION, 2022, 12 (03)
  • [7] A novel frameshift mutation in caveolin-1 associated with pulmonary arterial hypertension down-regulates caveolin-1 levels, reduces caveolae stability, and decreases the buffering capacity of caveolae.
    Han, B.
    Copeland, C. A.
    Drake, K. R.
    West, J.
    Austin, E.
    Loyd, J.
    Kenworthy, A. K.
    MOLECULAR BIOLOGY OF THE CELL, 2014, 25
  • [8] Impact of a frameshift mutant of caveolin-1 associated with pulmonary arterial hypertension on caveolae assembly and function.
    Copeland, C. A.
    Han, B.
    Kenworthy, A. K.
    Austin, E. D.
    West, J. D.
    Loyd, J. E.
    MOLECULAR BIOLOGY OF THE CELL, 2015, 26
  • [9] PHD2 Deficiency Induces Nitrative Stress via Suppression of Caveolin-1 in Pulmonary Arterial Hypertension
    Dai, Zhiyu
    Zhao, Youyang
    FASEB JOURNAL, 2019, 33
  • [10] Type I interferon activation and endothelial dysfunction in caveolin-1 insufficiency-associated pulmonary arterial hypertension
    Gairhe, Salina
    Awad, Keytam S.
    Dougherty, Edward J.
    Ferreyra, Gabriela A.
    Wang, Shuibang
    Yu, Zu-Xi
    Takeda, Kazuyo
    Demirkale, Cumhur Y.
    Torabi-Parizi, Parizad
    Austin, Eric D.
    Elinoff, Jason M.
    Danner, Robert L.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2021, 118 (11)
12