Natural Killer Cells: From Innate to Adaptive Features

被引：129

作者：

Mujal, Adriana M. ^{[1
]}

Delconte, Rebecca B. ^{[1
]}

Sun, Joseph C. ^{[1
,2
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Immunol Program, New York, NY 10065 USA

[2] Weill Cornell Med Coll, Dept Immunol & Microbial Pathogenesis, New York, NY 10065 USA

来源：

ANNUAL REVIEW OF IMMUNOLOGY, VOL 39 | 2021年 / 39卷

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

adaptive NK cell; innate immunity; immunological memory; MCMV; mouse cytomegalovirus; HCMV; human cytomegalovirus; NK-CELL; CUTTING EDGE; MURINE CYTOMEGALOVIRUS; CYTOTOXIC REACTIVITY; LYMPHOID-CELLS; MOUSE; MEMORY; RESISTANCE; RECEPTOR; EXPRESSION;

D O I：

10.1146/annurev-immunol-101819-074948

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Natural killer (NK) cells are innate lymphocytes that provide critical host defense against pathogens and cancer. Originally heralded for their early and rapid effector activity, NK cells have been recognized over the last decade for their ability to undergo adaptive immune processes, including antigendriven clonal expansion and generation of long-lived memory. This review presents an overview of how NK cells lithely partake in both innate and adaptive responses and how this versatility is manifest in human NK cell-mediated immunity.

引用

页码：417 / 447

页数：31

共 224 条

[1] Structural elucidation of the m157 mouse cytomegalovirus ligand for Ly49 natural killer cell receptors [J].

Adams, Erin J. ;

Juo, Z. Sean ;

Venook, Rayna Takaki ;

Boulanger, Martin J. ;

Arase, Hisashi ;

Garcia, K. Christopher .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (24) :10128-10133

[2] Cytomegalovirus Infection Drives Avidity Selection of Natural Killer Cells [J].

Adams, Nicholas M. ;

Geary, Clair D. ;

Santosa, Endi K. ;

Lumaquin, Dianne ;

Le Luduec, Jean-Benoit ;

Sottile, Rosa ;

van der Ploeg, Kattria ;

Hsu, Joy ;

Whitlock, Benjamin M. ;

Jackson, Benjamin T. ;

Weizman, Orr-El ;

Huse, Morgan ;

Hsu, Katharine C. ;

Sun, Joseph C. .

IMMUNITY, 2019, 50 (06) :1381-+

[3] Transcription Factor IRF8 Orchestrates the Adaptive Natural Killer Cell Response [J].

Adams, Nicholas M. ;

Lau, Colleen M. ;

Fan, Xiying ;

Rapp, Moritz ;

Geary, Clair D. ;

Weizman, Orr-El ;

Diaz-Salazar, Carlos ;

Sun, Joseph C. .

IMMUNITY, 2018, 48 (06) :1172-+

[4] Mouse Cytomegalovirus m153 Protein Stabilizes Expression of the Inhibitory NKR-P1B Ligand Clr-b [J].

Aguilar, Oscar A. ;

Sampaio, Isabella S. ;

Rahim, Mir Munir A. ;

Samaniego, Jackeline D. ;

Tilahun, Mulualem E. ;

Krishnamoorthy, Mithunah ;

Popovic, Branka ;

Babic, Marina ;

Krmpotic, Astrid ;

Treanor, Bebhinn ;

Margulies, David H. ;

Allan, David S. J. ;

Makrigiannis, Andrew P. ;

Jonjic, Stipan ;

Carlyle, James R. .

JOURNAL OF VIROLOGY, 2020, 94 (01)

[5] A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family [J].

Aguilar, Oscar A. ;

Berry, Richard ;

Rahim, Mir Munir A. ;

Reichel, Johanna J. ;

Popovic, Branka ;

Tanaka, Miho ;

Fu, Zhihui ;

Balaji, Gautham R. ;

Lau, Timothy N. H. ;

Tu, Megan M. ;

Kirkham, Christina L. ;

Mahmoud, Ahmad Bakur ;

Mesci, Aruz ;

Krmpotic, Astrid ;

Allan, David S. J. ;

Makrigiannis, Andrew P. ;

Jonjic, Stipan ;

Rossjohn, Jamie ;

Carlyle, James R. .

CELL, 2017, 169 (01) :58-+

[6] Anti-NKG2A mAb Is a Checkpoint Inhibitor that Promotes Anti-tumor Immunity by Unleashing Both T and NK Cells [J].

Andre, Pascale ;

Denis, Caroline ;

Soulas, Caroline ;

Bourbon-Caillet, Clarisse ;

Lopez, Julie ;

Arnoux, Thomas ;

Blery, Mathieu ;

Bonnafous, Cecile ;

Gauthier, Laurent ;

Morel, Ariane ;

Rossi, Benjamin ;

Remark, Romain ;

Breso, Violette ;

Bonnet, Elodie ;

Habif, Guillaume ;

Guia, Sophie ;

Lalanne, Ana Ines ;

Hoffmann, Caroline ;

Lantz, Olivier ;

Fayette, Jerome ;

Boyer-Chammard, Agnes ;

Zerbib, Robert ;

Dodion, Pierre ;

Ghadially, Hormas ;

Jure-Kunkel, Maria ;

Morel, Yannis ;

Herbst, Ronald ;

Narni-Mancinelli, Emilie ;

Cohen, Roger B. ;

Vivier, Eric .

CELL, 2018, 175 (07) :1731-+

[7] Functional interactions between dendritic cells and NK cells during viral infection [J].

Andrews, DM ;

Scalzo, AA ;

Yokoyama, WM ;

Smyth, MJ ;

Degli-Esposti, MA .

NATURE IMMUNOLOGY, 2003, 4 (02) :175-181

[8] Practical NK cell phenotyping and variability in healthy adults [J].

Angelo, Laura S. ;

Banerjee, Pinaki P. ;

Monaco-Shawver, Linda ;

Rosen, Joshua B. ;

Makedonas, George ;

Forbes, Lisa R. ;

Mace, Emily M. ;

Orange, Jordan S. .

IMMUNOLOGIC RESEARCH, 2015, 62 (03) :341-356

[9] Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors [J].

Arase, H ;

Mocarski, ES ;

Campbell, AE ;

Hill, AB ;

Lanier, LL .

SCIENCE, 2002, 296 (5571) :1323-1326

[10] A direct estimate of the human αβ T cell receptor diversity [J].

Arstila, TP ;

Casrouge, A ;

Baron, V ;

Even, J ;

Kanellopoulos, J ;

Kourilsky, P .

SCIENCE, 1999, 286 (5441) :958-961

← 1 2 3 4 5 6 7 8 9 10 →