Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives

被引：4

作者：

Yang, Xue Fei ^{[1
]}

Kong, Ling Yi ^{[1
]}

机构：

[1] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 210009, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2007年 / 18卷 / 04期

关键词：

2-aryl-5-alkyl-7-methoxylbenzo[b]furan; neolignans; synthesis; cytotoxicity;

D O I：

10.1016/j.cclet.2007.01.018

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3-methoxy-4-hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step. The structures of the new compounds were confirmed by H-1 NMR, IR and MS. The structure of compound 14 was further confirmed by single crystal X-ray. Compound 17 showed cytotoxic activity against human lung carcinoma A549. (c) 2007 Ling Yi Kong. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：380 / 382

页数：3

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