Erythromycin Molecularly Imprinted Two-dimensional Photonic Crystal Hydrogel Sensor

A molecularly imprinted two-dimensional photonic crystal hydrogel sensor was developed with erythromycin as imprinted molecule, polystyrene two-dimensional photonic crystal as templates, methanol as solvent, methacrylic acid as monomers and ethylene glycol dimethylacrylate as cross-linkers. The imprinted molecule was removed by methanol/acetic acid (9:1, V/V). The results showed that the diameter of Debye ring increased 6 mm when the concentration of EM changed from 0 to 1. 10(-6) mol/L. Namely the lattice spacing decreased 30 nm. In addition, the diameter of Debye ring only increased 1. 5 and 2. 0 mm when the hydrogel immersed in 1. 10(-6) mol/L roxithromycin (RM) or erythromycin ethylsuccinate (EEs) solution. The result indicated that the sensor had high selectivity and could be used in determination of erythromycin with low cost and easy operation.