Short Communication: Resolution of Tenofovir Disoproxil Fumarate Induced Fanconi Syndrome with Switch to Tenofovir Alafenamide Fumarate in a HIV-1 and Hepatitis B Coinfected Patient

被引：4

作者：

Karris, Maile Young ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, 200 West Arbor Dr Mail Code 8208, San Diego, CA 92103 USA

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2017年 / 33卷 / 07期

基金：

美国国家卫生研究院;

关键词：

HIV; hepatitis B; tenofovir alafenamide; Fanconi syndrome; OPEN-LABEL PHASE-3; INFECTED ADULTS; SINGLE-ARM; EMTRICITABINE; ELVITEGRAVIR; IMPAIRMENT; COBICISTAT; MULTICENTER; VIRUS;

D O I：

10.1089/aid.2016.0180

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fanconi syndrome is a rare adverse effect of tenofovir disoproxil fumarate (TDF). Tenofovir alafenamide fumarate (TAF) is a novel prodrug with less nephrotoxicity. We report resolution of Fanconi syndrome in a HIV and hepatitis B coinfected patient switched from TDF to TAF.

引用

页码：718 / 722

页数：5

共 13 条

[1] Tenofovir alafenamide is not a substrate for renal organic anion transporters (OATs) and does not exhibit OAT-dependent cytotoxicity [J].

Bam, Rujuta A. ;

Yant, Stephen R. ;

Cihlar, Tomas .

ANTIVIRAL THERAPY, 2014, 19 (07) :687-692

[2]

Buti M, 2016, PHASE 3 STUDY TENOFO

[3] Long-term Therapy With Tenofovir Is Effective for Patients Co-Infected With Human Immunodeficiency Virus and Hepatitis B Virus [J].

de Vries-Sluijs, Theodora E. M. S. ;

Reijnders, Jurrien G. P. ;

Hansen, Bettina E. ;

Zaaijer, Hans L. ;

Prins, Jan M. ;

Pas, Suzan D. ;

Schutten, Martin ;

Hoepelman, Andy I. M. ;

Richter, Clemens ;

Mulder, Jan W. ;

de Man, Rob A. ;

Janssen, Harry L. A. ;

van der Ende, Marchina E. .

GASTROENTEROLOGY, 2010, 139 (06) :1934-1941

[4]

Gallant J, 2015, IAS 2015

[5] First case report of renal improvement on tenofovir alafenamide in an HIV/hepatitis B virus-coinfected patient with adefovir-induced Fanconi's syndrome [J].

Garcia, Magali ;

Le Moal, Gwenael ;

Godet, Cendrine ;

Beraud, Guillaume ;

Chagneau-Derrode, Carine ;

Roblot, France .

AIDS, 2016, 30 (09) :1487-1488

[6] Tenofovir-associated Fanconi syndrome in patients with chronic hepatitis B monoinfection [J].

Gracey, David M. ;

Snelling, Paul ;

McKenzie, Paul ;

Strasser, Simone I. .

ANTIVIRAL THERAPY, 2013, 18 (07) :945-948

[7] Tenofovir nephrotoxicity: acute tubular necrosis with distinctive clinical, pathological, and mitochondrial abnormalities [J].

Herlitz, Leal C. ;

Mohan, Sumit ;

Stokes, Michael B. ;

Radhakrishnan, Jai ;

D'Agati, Vivette D. ;

Markowitz, Glen S. .

KIDNEY INTERNATIONAL, 2010, 78 (11) :1171-1177

[8] Phase I/II study of the pharmacokinetics, safety and antiretroviral activity of tenofovir alafenamide, a new prodrug of the HIV reverse transcriptase inhibitor tenofovir, in HIV-infected adults [J].

Markowitz, Martin ;

Zolopa, Andrew ;

Squires, Kathleen ;

Ruane, Peter ;

Coakley, Dion ;

Kearney, Brian ;

Zhong, Lijie ;

Wulfsohn, Michael ;

Miller, Michael D. ;

Lee, William A. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (05) :1362-1369

[9] Tenofovir alafenamide as part of a salvage regimen in a patient with multi-drug resistant HIV and tenofovir-DF-associated renal tubulopathy [J].

Mikula, James M. ;

Manion, Maura M. ;

Maldarelli, Frank ;

Suarez, Lucila M. ;

Norman-Wheeler, Jaha F. ;

Ober, Alex G. ;

Dewar, Robin L. ;

Kopp, Jeffrey B. ;

Lane, H. Clifford ;

Pau, Alice K. .

ANTIVIRAL THERAPY, 2016, 21 (06) :553-558

[10] Switching to Tenofovir Alafenamide, Coformulated With Elvitegravir, Cobicistat, and Emtricitabine, in HIV-Infected Adults With Renal Impairment: 96-Week Results From a Single-Arm, Multicenter, Open-Label Phase 3 Study [J].

Post, Frank A. ;

Tebas, Pablo ;

Clarke, Amanda ;

Cotte, Laurent ;

Short, William R. ;

Abram, Michael E. ;

Jiang, Shuping ;

Cheng, Andrew ;

Das, Moupali ;

Fordyce, Marshall W. .

JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES, 2017, 74 (02) :180-184

← 1 2 →