Marked and independent prognostic significance of the CpG island methylator phenotype in neuroblastomas

被引：36
作者：
Abe, Masanobu
Westermann, Frank
Nakagawara, Akira
Takato, Tsuyoshi
Schwab, Manfred
Ushijima, Toshikazu
机构：
[1] Univ Tokyo, Grad Sch Med, Natl Canc Ctr,Chuo Ku, Inst Res,Carcinogenesis Div, Tokyo 1040045, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Oral & Maxillofacial Surg, Tokyo 1040045, Japan
[3] German Canc Res Ctr, Div Tumor Genet, D-6900 Heidelberg, Germany
[4] Chiba Canc Ctr, Inst Res, Div Biochem, Chiba, Japan
来源：
CANCER LETTERS | 2007年 / 247卷 / 02期
关键词：
neuroblastoma; methylation; CIMP; MS-RDA; n-myc;
D O I：
10.1016/j.canlet.2006.05.001
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The CpG island methylator phenotype (ClMP) was closely associated with poor overall survival (OS) in Japanese neuroblastoma (NBL) cases in our previous study. Here, in German NBL cases, CIMP(+) cases (n = 95) showed markedly poorer OS (hazard ratio (HR) = 9.5; P < 0.0001) and disease-free survival (DFS) (HR = 5.4; P < 0.0001) than CIMP(-) cases (n = 50). All the 23 cases with N-myc amplification had CIMP. Among the remaining cases without N-myc amplification, CIMP(+) cases (n 27) had a poorer OS (HR = 4.5; P = 0.02) and DFS (HR = 5.2; P < 0.0001) than CIMP(-) cases (n = 95). In multivariate analysis, CIMP and N-myc amplification had an influence on OS and DFS independent of age and disease stage. CIMP had a stronger influence on DFS than N-myc amplification while N-myc had a stronger influence on OS. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：253 / 258
页数：6
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