Characterization of calumenin in mouse heart

被引:35
作者
Sahoo, Sanjaya Kumar
Kim, Do Han [1 ]
机构
[1] GIST, Dept Life Sci, Kwangju 500712, South Korea
关键词
Excitation-contraction coupling; Mammalian heart; Ryanodine receptor; SERCA; Striated muscle; Systems biology; CALCIUM-BINDING PROTEIN; DEPENDENT GAMMA-CARBOXYLATION; MULTIPLE EF-HAND; SARCOPLASMIC-RETICULUM; CA2+-BINDING PROTEIN; ENDOPLASMIC-RETICULUM; SECRETORY PATHWAY; MOLECULAR-BASIS; HISTIDINE-RICH; RETICULOCALBIN;
D O I
10.5483/BMBRep.2010.43.3.158
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Calumenin is a multiple EF-hand Ca2+-binding protein located in the endo/sarcoplasmic reticulum of mammalian hearts. Calumenin belongs to the CREC family of Ca2+-binding proteins having multiple EF-hands. Ca2+ homeostasis in the sarcoplasmic reticulum (SR) of mammalian hearts is maintained by RyR2, SERCA2 and other associated SR resident proteins. Evidence suggests that calumenin interacts with RyR2 and SERCA2, and therefore changes in the expression of calumenin could alter Ca2+ cycling in mouse heart. In this review, current knowledge of the biochemical and functional roles of calumenin in mouse heart is described. [BMB reports 2010; 43(3): 158-163]
引用
收藏
页码:158 / 163
页数:6
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