Hydroxoiridium-Catalyzed sp3 C-H Alkylation of Indoline Derivatives with Terminal Alkenes

被引：11
|
作者：
Nakamura, Ikumi [1 ]
Yamauchi, Daisuke [2 ]
Nishimura, Takahiro [1 ]
机构：
[1] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi Ku, Osaka 5588585, Japan
[2] Kyoto Univ, Grad Sch Sci, Dept Chem, Kyoto 6068502, Japan
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 7卷 / 07期
关键词：
alkenes; C-H activation; indolines; iridium; synthetic methods; C(SP(3))-H ALPHA-ALKYLATION; BOND ACTIVATION; VINYL ETHERS; INTERMOLECULAR HYDROAMINOALKYLATION; SELECTIVE HYDROARYLATION; COUPLING REACTION; FUNCTIONALIZATION; ADJACENT; NITROGEN; MECHANISM;
D O I：
10.1002/ajoc.201800189
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Direct alkylation of a secondary sp(3) C-H bond of indoline derivatives having a urea moiety with terminal alkenes proceeded in the presence of a hydroxoiridium/1,5-cyclooctadiene catalyst, which generated an amidoiridium intermediate by reaction with a urea N-H moiety of the indolines, giving the linear addition products in high yields.
引用
收藏
页码：1347 / 1350
页数：4
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