The non-heme diiron alkane monooxygenase of Pseudomonas oleovorans (AlkB) hydroxylates via a substrate radical intermediate

被引：69

作者：

Austin, RN

Chang, HK

Zylstra, GJ

Groves, JT ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem, Princeton, NJ 08544 USA

[2] Rutgers State Univ, Biotechnol Ctr Agr & Environm, New Brunswick, NJ 08901 USA

[3] Bates Coll, Dept Chem, Lewiston, ME 04240 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2000年 / 122卷 / 47期

关键词：

D O I：

10.1021/ja001500v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：11747 / 11748

页数：2

共 32 条

[1] CYTOCHROME P450-CATALYZED HYDROXYLATION OF HYDROCARBONS - KINETIC DEUTERIUM-ISOTOPE EFFECTS FOR THE HYDROXYLATION OF AN ULTRAFAST RADICAL CLOCK [J].

ATKINSON, JK ;

HOLLENBERG, PF ;

INGOLD, KU ;

JOHNSON, CC ;

LETADIC, MH ;

NEWCOMB, M ;

PUTT, DA .

BIOCHEMISTRY, 1994, 33 (35) :10630-10637

[2] PRODUCTION OF PRIMARY ALIPHATIC-ALCOHOLS WITH A RECOMBINANT PSEUDOMONAS STRAIN, ENCODING THE ALKANE HYDROXYLASE ENZYME-SYSTEM [J].

BOSETTI, A ;

VANBEILEN, JB ;

PREUSTING, H ;

LAGEVEEN, RG ;

WITHOLT, B .

ENZYME AND MICROBIAL TECHNOLOGY, 1992, 14 (09) :702-708

[3] CALIBRATION OF A NEW HOROLOGERY OF FAST RADICAL CLOCKS - RING-OPENING RATES FOR RING-ALKYL-SUBSTITUTED AND ALPHA-ALKYL-SUBSTITUTED CYCLOPROPYLCARBINYL RADICALS AND FOR THE BICYCLO[2.1.0]PENT-2-YL RADICAL [J].

BOWRY, VW ;

LUSZTYK, J ;

INGOLD, KU .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1991, 113 (15) :5687-5698

[4] STEREOSPECIFIC HYDROXYLATION OF INDAN BY ESCHERICHIA-COLI CONTAINING THE CLONED TOLUENE DIOXYGENASE GENES FROM PSEUDOMONAS-PUTIDA F1 [J].

BRAND, JM ;

CRUDEN, DL ;

ZYLSTRA, GJ ;

GIBSON, DT .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1992, 58 (10) :3407-3409

[5] KINETICS AND RATE CONSTANTS FOR REDUCTION OF ALKYL HALIDES BY ORGANOTIN HYDRIDES [J].

CARLSSON, DJ ;

INGOLD, KU .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1968, 90 (25) :7047-&

[6] Cationic species can be produced in soluble methane monooxygenase-catalyzed hydroxylation reactions; radical intermediates are not formed [J].

Choi, SY ;

Eaton, PE ;

Kopp, DA ;

Lippard, SJ ;

Newcomb, M ;

Shen, RN .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (51) :12198-12199

[7]

CHOI SY, 1996, J AM CHEM SOC, V118, P6457

[8]

DEMONTELLANO PRO, 1987, J AM CHEM SOC, V109, P3415

[9] REACTIONS OF NONHEME IRON(II) CENTERS WITH DIOXYGEN IN BIOLOGY AND CHEMISTRY [J].

FEIG, AL ;

LIPPARD, SJ .

CHEMICAL REVIEWS, 1994, 94 (03) :759-805

[10] CYCLOPROPYLCARBINYL-ALLYLCARBINYL RADICAL REARRANGEMENTS IN SIMPLE BICYCLO[3.1.0)HEXYL AND BICYCLO[4.1.0]HEPTYL SYSTEMS [J].

FRIEDRICH, EC ;

HOLMSTEA.RL .

JOURNAL OF ORGANIC CHEMISTRY, 1972, 37 (16) :2550-+

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