Visible light triggered, catalyst free approach for the synthesis of thiazoles and imidazo[2,1-b]thiazoles in EtOH : H2O green medium

被引：49

作者：

Mishra, Anu ^{[1
]}

Srivastava, Madhulika ^{[1
]}

Rai, Pratibha ^{[1
]}

Yadav, Snehlata ^{[1
]}

Tripathi, Bhartendu Pati ^{[1
]}

Singh, Jaya ^{[2
]}

Singh, Jagdamba ^{[1
]}

机构：

[1] Univ Allahabad, Dept Chem, Environm Benign Synth Lab, Allahabad 211002, Uttar Pradesh, India

[2] LRPG Coll, Dept Chem, Sahibabad, Uttar Pradesh, India

来源：

RSC ADVANCES | 2016年 / 6卷 / 54期

关键词：

AEROBIC OXIDATIVE CYCLIZATION; ONE-POT SYNTHESIS; 2,4-DISUBSTITUTED THIAZOLES; 1,4-DIHYDROPYRIDINE SCAFFOLD; ANTIMICROBIAL EVALUATION; BIOLOGICAL EVALUATION; PHOTOREDOX CATALYSIS; MEDICINAL CHEMISTRY; ANTITUMOR-ACTIVITY; METAL-FREE;

D O I：

10.1039/c6ra05385h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of a visible light promoted, mild and greener approach for the synthesis of highly functionalized thiazoles and imidazo[2,1-b]thiazoles under photochemical activation in EtOH : H2O green medium is demonstrated. The characteristic feature of the present protocol is the utilization of visible light (an omnipresent, nontoxic, environmentally benign and inexpensive reagent) to form C-S and C-N bonds and circumvent the use of catalysts or photosensitizers. The reported protocol is the first example of visible light promoted synthesis of thiazoles and imidazo[2,1-b]thiazoles with various attractive features like being catalyst free, eco-efficient and possessing cost effectiveness, short reaction time, excellent yields and sustainability to fulfill the parameters of green chemistry.

引用

页码：49164 / 49172

页数：9

共 101 条

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