Pseudoverticin, a novel benzoquinone-derived ansamycin antibiotic obtained as new cell cycle inhibitor from Streptomyces pseudoverticillus YN17707

被引：5
作者：
Cui, Cheng-Bin
Han, Bing
Cai, Bing
Wang, Hao
机构：
[1] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
[2] Beijing Inst Biomed, Beijing 100091, Peoples R China
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 28期
基金：
中国国家自然科学基金;
关键词：
Pseudoverticin; geldanamycin; Streptomyces pseudoverticillus; ansamycin antibiotic; cell cycle inhibitor; structure;
D O I：
10.1016/j.tetlet.2007.05.052
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Pseudoverticin (1), a novel benzoquinone-derived ansamycin antibiotic showing cell cycle inhibitory activity, was isolated from the fermentation broth of Streptomyces pseudoverticillus YN17707 together with the known ansamycin antibiotic geldanamycin (2) through a bioassay-guided separation procedure. The structure of 1 was elucidated by spectroscopic methods, being characterized by an ansa bridge the same as that in 2 and a novel benzoquinone-derived moiety. Pseudoverticin (1) arrested the cell cycle of tsFT210 cells at the G0/G1 phase with the MIC value of 2.5 mu M. (c) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：4839 / 4843
页数：5
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