A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo

被引：82

作者：

Essex-Lopresti, AE ^{[1
]}

Boddey, JA

Thomas, R

Smith, MP

Hartley, MG

Atkins, T

Brown, NF

Tsang, CH

Peak, IRA

Hill, J

Beacham, IR

Titball, RW

机构：

[1] Dstl Porton Down, Salisbury SP4 0JQ, Wilts, England

[2] Griffith Univ, Inst Glycom, Gold Coast, Qld, Australia

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 02期

关键词：

D O I：

10.1128/IAI.73.2.1260-1264.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.

引用

页码：1260 / 1264

页数：5

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