A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo

被引：81
|
作者：
Essex-Lopresti, AE [1 ]
Boddey, JA
Thomas, R
Smith, MP
Hartley, MG
Atkins, T
Brown, NF
Tsang, CH
Peak, IRA
Hill, J
Beacham, IR
Titball, RW
机构：
[1] Dstl Porton Down, Salisbury SP4 0JQ, Wilts, England
[2] Griffith Univ, Inst Glycom, Gold Coast, Qld, Australia
来源：
INFECTION AND IMMUNITY | 2005年 / 73卷 / 02期
关键词：
D O I：
10.1128/IAI.73.2.1260-1264.2005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.
引用
收藏
页码：1260 / 1264
页数：5
相关论文
共 44 条
  • [11] Disarming Burkholderia pseudomallei: Structural and Functional Characterization of a Disulfide Oxidoreductase (DsbA) Required for Virulence In Vivo
    Ireland, Philip M.
    McMahon, Roisin M.
    Marshall, Laura E.
    Halili, Maria
    Furlong, Emily
    Tay, Stephanie
    Martin, Jennifer L.
    Sarkar-Tyson, Mitali
    ANTIOXIDANTS & REDOX SIGNALING, 2014, 20 (04) : 606 - 617
  • [12] The Cluster 1 Type VI Secretion System Is a Major Virulence Determinant in Burkholderia pseudomallei
    Burtnick, Mary N.
    Brett, Paul J.
    Harding, Sarah V.
    Ngugi, Sarah A.
    Ribot, Wilson J.
    Chantratita, Narisara
    Scorpio, Angelo
    Milne, Timothy S.
    Dean, Rachel E.
    Fritz, David L.
    Peacock, Sharon J.
    Prior, Joanne L.
    Atkins, Timothy P.
    DeShazer, David
    INFECTION AND IMMUNITY, 2011, 79 (04) : 1512 - 1525
  • [13] Truncated type IV pilin PilA108 activates the intramembrane protease AlgW to cleave MucA and PilA108 itself in vitro
    Ronghui Li
    Ryan T. Withers
    Jingcheng Dai
    Jing Ruan
    Wei Li
    Yujun Dai
    Weixing An
    Dianzhen Yu
    Hehong Wei
    Ming Xia
    Chunyuan Tian
    Hongwei D. Yu
    Dongru Qiu
    Archives of Microbiology, 2016, 198 : 885 - 892
  • [14] Truncated type IV pilin PilA108 activates the intramembrane protease AlgW to cleave MucA and PilA108 itself in vitro
    Li, Ronghui
    Withers, Ryan T.
    Dai, Jingcheng
    Ruan, Jing
    Li, Wei
    Dai, Yujun
    An, Weixing
    Yu, Dianzhen
    Wei, Hehong
    Xia, Ming
    Tian, Chunyuan
    Yu, Hongwei D.
    Qiu, Dongru
    ARCHIVES OF MICROBIOLOGY, 2016, 198 (09) : 885 - 892
  • [15] OxyR contributes to virulence of Acidovorax citrulli by regulating anti-oxidative stress and expression of flagellin FliC and type IV pili PilA
    Wang, Jianan
    Liu, Jun
    Zhao, Yuqiang
    Sun, Minghui
    Yu, Guixu
    Fan, Jiaqin
    Tian, Yanli
    Hu, Baishi
    FRONTIERS IN MICROBIOLOGY, 2022, 13
  • [16] Role for the Burkholderia pseudomallei Type Three Secretion System Cluster 1 bpscN Gene in Virulence
    D'Cruze, Tanya
    Gong, Lan
    Treerat, Puthayalai
    Ramm, Georg
    Boyce, John D.
    Prescott, Mark
    Adler, Ben
    Devenish, Rodney J.
    INFECTION AND IMMUNITY, 2011, 79 (09) : 3659 - 3664
  • [17] The hypothetical type VI secretion protein BPSS1504 is involved in virulence of Burkholderia pseudomallei
    Hopf, V.
    Bast, A.
    Steinmetz, I.
    Breitbach, K.
    INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2011, 301 : 75 - 75
  • [18] An Aeromonas salmonicida type IV pilin is required for virulence in rainbow trout Oncorhynchus mykiss
    Masada, CL
    LaPatra, SE
    Morton, AW
    Strom, MS
    DISEASES OF AQUATIC ORGANISMS, 2002, 51 (01) : 13 - 25
  • [19] Comparative in vivo and in vitro analyses of putative virulence factors of Burkholderia pseudomallei using lipopolysaccharide, capsule and flagellin mutants
    Wikraiphat, Chanthiwa
    Charoensap, Jaruek
    Utaisincharoen, Pongsak
    Wongratanacheewin, Surasakdi
    Taweechaisupapong, Suwimol
    Woods, Donald E.
    Bolscher, Jan G. M.
    Sirisinha, Stitaya
    FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 2009, 56 (03): : 253 - 259
  • [20] Relatedness of type IV pilin PilA amongst geographically diverse Moraxella bovoculi isolated from cattle with infectious bovine keratoconjunctivitis
    Angelos, John A.
    Clothier, Kristin A.
    Agulto, Regina L.
    Mandzyuk, Boguslav
    Tryland, Morten
    JOURNAL OF MEDICAL MICROBIOLOGY, 2021, 70 (02)
12345