A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallei and virulence in vivo

被引：81
|
作者：
Essex-Lopresti, AE [1 ]
Boddey, JA
Thomas, R
Smith, MP
Hartley, MG
Atkins, T
Brown, NF
Tsang, CH
Peak, IRA
Hill, J
Beacham, IR
Titball, RW
机构：
[1] Dstl Porton Down, Salisbury SP4 0JQ, Wilts, England
[2] Griffith Univ, Inst Glycom, Gold Coast, Qld, Australia
来源：
INFECTION AND IMMUNITY | 2005年 / 73卷 / 02期
关键词：
D O I：
10.1128/IAI.73.2.1260-1264.2005
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.
引用
收藏
页码：1260 / 1264
页数：5
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