Enantioselective synthetic method for 3-hydroxyflavanones:: an approach to (2R,3R)-3′,4′-O-dimethyltaxifolin

被引：22

作者：

Jew, S ^{[1
]}

Kim, H ^{[1
]}

Bae, S ^{[1
]}

Kim, J ^{[1
]}

Park, H ^{[1
]}

机构：

[1] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 41期

基金：

新加坡国家研究基金会;

关键词：

3-hydroxyflavanone; asymmetric dihydroxylation; intramolecular Mitsunobu reaction; (2R; 3R)-3; 4; '-O-dimethyltaxifolin;

D O I：

10.1016/S0040-4039(00)01382-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new enantioselective synthetic method for (2R,3R)-3-hydroxyflavanone (1a) was developed via asymmetric dihydroxylation (ADH) and intramolecular Mitsunobu reaction as key reactions and the application to synthesis of (2R,3R)-3',4'-O-dimethyltaxifolin (1b) is described. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7925 / 7928

页数：4

共 14 条

[1]

BOHM BA, 1994, FLAVONOIDS ADV RES 1, P419

[2]

CAVALLINI L, 1976, GAZZ MED ITAL, V125, P365

[3] NUCLEAR MAGNETIC-RESONANCE ENANTIOMER REAGENTS - CONFIGURATIONAL CORRELATIONS VIA NUCLEAR MAGNETIC-RESONANCE CHEMICAL-SHIFTS OF DIASTEREOMERIC MANDELATE, O-METHYLMANDELATE, AND ALPHA-METHOXY-ALPHA-TRIFLUOROMETHYLPHENYLACETATE (MTPA) ESTERS [J].