Past, present and future targets for immunotherapy in ovarian cancer

被引：41

作者：

Schwab, Carlton L. ^{[1
]}

English, Diana P. ^{[1
]}

Roque, Dana M. ^{[1
]}

Pasternak, Monica ^{[1
]}

Santin, Alessandro D. ^{[1
]}

机构：

[1] Yale Univ, Sch Med, Div Gynecol Oncol, Dept Obstet Gynecol & Reprod Sci, New Haven, CT 06520 USA

来源：

IMMUNOTHERAPY | 2014年 / 6卷 / 12期

关键词：

adoptive transfer; CA125; EpCAM; mesothelin; NY-ESO-1; ovarian cancer; p53; tumor associated antigens; tumor vaccines; WT-1; REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; PEPTIDE-BASED IMMUNOTHERAPY; PULSED DENDRITIC CELLS; FOLATE RECEPTOR-ALPHA; PHASE-I TRIAL; ANTITUMOR IMMUNITY; ADOPTIVE TRANSFER; STEM-CELLS; EP-CAM;

D O I：

10.2217/imt.14.90

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Ovarian cancer is the leading cause of death from gynecologic malignancy in the US. Treatments have improved with conventional cytotoxic chemotherapy and advanced surgical techniques but disease recurrence is common and fatal in nearly all cases. Current evidence suggests that the immune system and its ability to recognize and eliminate microscopic disease is paramount in preventing recurrence. Ovarian cancer immunotherapy is targeting tumors through active, passive and adoptive approaches. The goal of immunotherapy is to balance the activation of the immune system against cancer while preventing the potential for tremendous toxicity elicited by immune modulation. In this paper we will review the different immunotherapies available for ovarian cancer as well as current ongoing studies and potential future directions.

引用

页码：1279 / 1293

页数：15

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