Context: Evidence suggests that concussion prolongs reaction time (RT). We have developed a simple, reliable clinical tool for measuring reaction time that may be of value in the assessment of concussion in athletes. Objective: To compare baseline values of clinical AT (RTclin) obtained using the new clinical reaction time apparatus with computerized AT (RTcomp) obtained using a validated computerized neuropsychological test battery. Design: Cross-sectional study. Setting: Data were collected during a National Collegiate Athletic Association Division I collegiate football team's preparticipation physical examination session. Patients or Other Participants: Ninety-four Division I collegiate football players. Main Outcome Measure(s): The RTclin was measured using a 1.3-m measuring stick embedded in a weighted rubber disk that was released and caught as quickly as possible. The RTcomp was measured using the simple AT component of Cog State Sport. Results: For the 68 athletes whose CogState Sport tests passed the program's integrity check, RTclin and RTcomp were correlated (r = 0.445, P < .001). Overall, mean RTclin was shorter and less variable than mean RTcomp (203 +/- 20 milliseconds versus 268 +/- 44 milliseconds; P <.001). When RTclin and RTcomp were compared between those athletes with (n = 68) and those without (n = 26) valid CogState Sport test sessions, mean RTcli, was similar (202 +/- 19 milliseconds versus 207 +/- 23 milliseconds; P = .390), but mean RTclin was different (258 +/- 35 milliseconds versus 290 55 milliseconds; P = .009). Conclusions: The RTclin was positively correlated with RTclin and yielded more consistent reaction time values during baseline testing. Given that RTclin is easy to measure using simple, inexpensive equipment, further prospective study is warranted to determine its clinical utility in the assessment of concussion in athletes.