Neurological pathogenesis of SARS-CoV-2 (COVID-19): from virological features to clinical symptoms

被引:10
作者
Kase, Yoshitaka [1 ,2 ]
Okano, Hideyuki [1 ]
机构
[1] Keio Univ, Sch Med, Dept Physiol, Shinjuku Ku, 35 Shinanomachi, Tokyo 1608582, Japan
[2] Univ Tokyo, Grad Sch Med, Dept Geriatr Med, Bunkyo Ku, Tokyo 1138655, Japan
关键词
Coronavirus (CoV); COVID-19; Neural disorder; SARS-CoV-2; SYNDROME CORONAVIRUS INFECTION; VIRUS; RECEPTOR; BRAIN; IDENTIFICATION; ENCEPHALITIS; CELLS; ACE2; HKU1;
D O I
10.1186/s41232-021-00165-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Since the worldwide outbreak of coronavirus disease 2019 (COVID-19) in 2020, various research reports and case reports have been published. It has been found that COVID-19 causes not only respiratory disorders but also thrombosis and gastrointestinal disorders, central nervous system (CNS) disorders, and peripheral neuropathy. Compared to other disorders, there are low number of research reports and low number of summaries on COVID-19-related neural disorders. Therefore, focusing on neural disorders, we outline both basic research and clinical manifestations of COVID-19-related neural disorders.
引用
收藏
页数:7
相关论文
共 52 条
  • [1] The proximal origin of SARS-CoV-2
    Andersen, Kristian G.
    Rambaut, Andrew
    Lipkin, W. Ian
    Holmes, Edward C.
    Garry, Robert F.
    [J]. NATURE MEDICINE, 2020, 26 (04) : 450 - 452
  • [2] [Anonymous], COR DIS COVID 19 PAN
  • [3] Severe neurologic syndrome associated with Middle East respiratory syndrome corona virus (MERS-CoV)
    Arabi, Y. M.
    Harthi, A.
    Hussein, J.
    Bouchama, A.
    Johani, S.
    Hajeer, A. H.
    Saeed, B. T.
    Wahbi, A.
    Saedy, A.
    AlDabbagh, T.
    Okaili, R.
    Sadat, M.
    Balkhy, H.
    [J]. INFECTION, 2015, 43 (04) : 495 - 501
  • [4] Neuroinvasion by human respiratory coronaviruses
    Arbour, N
    Day, R
    Newcombe, J
    Talbot, PJ
    [J]. JOURNAL OF VIROLOGY, 2000, 74 (19) : 8913 - 8921
  • [5] Acute and persistent infection of human neural cell lines by human coronavirus OC43
    Arbour, N
    Côté, G
    Lachance, C
    Tardieu, M
    Cashman, NR
    Talbot, PJ
    [J]. JOURNAL OF VIROLOGY, 1999, 73 (04) : 3338 - 3350
  • [6] CHARACTERIZATION OF AN EFFICIENT CORONAVIRUS RIBOSOMAL FRAMESHIFTING SIGNAL - REQUIREMENT FOR AN RNA PSEUDOKNOT
    BRIERLEY, I
    DIGARD, P
    INGLIS, SC
    [J]. CELL, 1989, 57 (04) : 537 - 547
  • [7] Gill-associated virus of Penaeus monodon prawns:: an invertebrate virus with ORF1a and ORF1b genes related to arteri- and coronaviruses
    Cowley, JA
    Dimmock, CM
    Spann, KM
    Walker, PJ
    [J]. JOURNAL OF GENERAL VIROLOGY, 2000, 81 : 1473 - 1484
  • [8] Identification of a novel coronavirus in patients with severe acute respiratory syndrome
    Drosten, C
    Günther, S
    Preiser, W
    van der Werf, S
    Brodt, HR
    Becker, S
    Rabenau, H
    Panning, M
    Kolesnikova, L
    Fouchier, RAM
    Berger, A
    Burguière, AM
    Cinatl, J
    Eickmann, M
    Escriou, N
    Grywna, K
    Kramme, S
    Manuguerra, JC
    Müller, S
    Rickerts, V
    Stürmer, M
    Vieth, S
    Klenk, HD
    Osterhaus, ADME
    Schmitz, H
    Doerr, HW
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (20) : 1967 - 1976
  • [9] Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43
    Dube, Mathieu
    Le Coupanec, Alain
    Wong, Alan H. M.
    Rini, James M.
    Desforges, Marc
    Talbot, Pierre J.
    [J]. JOURNAL OF VIROLOGY, 2018, 92 (17)
  • [10] Neuroimmune Axes of the Blood-Brain Barriers and Blood-Brain Interfaces: Bases for Physiological Regulation, Disease States, and Pharmacological Interventions
    Erickson, Michelle A.
    Banks, William A.
    [J]. PHARMACOLOGICAL REVIEWS, 2018, 70 (02) : 278 - 314