Perspectives of Liquid Chromatography Coupled to Low- and High-Resolution Mass Spectrometry for Screening, Identification, and Quantification of Drugs in Clinical and Forensic Toxicology

被引：55
|
作者：
Maurer, Hans H. [1 ]
机构：
[1] Univ Saarland, Dept Expt & Clin Toxicol, Inst Expt & Clin Pharmacol & Toxicol, D-66421 Homburg, Saar, Germany
来源：
THERAPEUTIC DRUG MONITORING | 2010年 / 32卷 / 03期
关键词：
LC-MS/MS; screening; quantification; clinical toxicology; forensic toxicology; REACTION-MONITORING MODE; LC-MS-MS; HUMAN URINE; DIRECT-INJECTION; DESIGNER DRUGS; DOPING CONTROL; ILLICIT DRUGS; ORAL FLUID; METABOLISM; ABUSE;
D O I：
10.1097/FTD.0b013e3181dca295
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
This article reviews papers on the use of liquid chromatography coupled to low- and high-resolution mass spectrometry in clinical and forensic toxicology. They cover procedures for target and for more comprehensive screening for drugs (of abuse), identification of drug metabolites, and multianalyte procedures for quantification of drugs and/or their metabolites in body samples. Besides a critical overview, perspectives are discussed.
引用
收藏
页码：324 / 327
页数：4
相关论文
共 50 条
  • [1] Characterization of Ganstigmine metabolites in hepatocytes by low- and high-resolution mass spectrometry coupled with liquid chromatography
    Pelizzi, N
    Puccini, P
    Riccardi, B
    Acerbi, D
    Catinella, S
    RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2003, 17 (15) : 1691 - 1698
  • [2] Liquid chromatography mass spectrometry in forensic and clinical toxicology
    Maurer, HH
    JOURNAL OF CHROMATOGRAPHY B, 1998, 713 (01): : 3 - 25
  • [3] Simultaneous Analysis of Drugs in Forensic Cases by Liquid Chromatography–High-Resolution Orbitrap Mass Spectrometry
    Siti U. Mokhtar
    Chadin Kulsing
    Jalal T. Althakafy
    Alex Kotsos
    Olaf H. Drummer
    Philip J. Marriott
    Chromatographia, 2020, 83 : 53 - 64
  • [4] Impurity identification and quantification for arginine vasopressin by liquid chromatography/high-resolution mass spectrometry
    Wu, Peize
    Ye, Sijian
    Li, Ming
    Li, Hongmei
    Kan, Ying
    Yang, Zecheng
    RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2020, 34 (12)
  • [5] Liquid chromatography coupled to high-resolution mass spectrometry for nut classification and marker identification
    Campmajo, Guillem
    Saurina, Javier
    Nunez, Oscar
    FOOD CONTROL, 2023, 152
  • [6] Benefits of High-Resolution Mass Spectrometry in a Forensic Toxicology Laboratory
    不详
    LC GC NORTH AMERICA, 2020, 38 (07) : 398 - 399
  • [7] Forensic drug screening by liquid chromatography hyphenated with high-resolution mass spectrometry (LC-HRMS)
    Heinsvig, Pia Johansson
    Noble, Carolina
    Dalsgaard, Petur Weihe
    Mardal, Marie
    TRAC-TRENDS IN ANALYTICAL CHEMISTRY, 2023, 162
  • [8] Current use of high-resolution mass spectrometry in drug screening relevant to clinical and forensic toxicology and doping control
    Ojanpera, Ilkka
    Kolmonen, Marjo
    Pelander, Anna
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 403 (05) : 1203 - 1220
  • [9] Current use of high-resolution mass spectrometry in drug screening relevant to clinical and forensic toxicology and doping control
    Ilkka Ojanperä
    Marjo Kolmonen
    Anna Pelander
    Analytical and Bioanalytical Chemistry, 2012, 403 : 1203 - 1220
  • [10] Current role of liquid chromatography coupled to mass spectrometry in clinical toxicology screening methods
    Viette, Veronique
    Fathi, Marc
    Rudaz, Serge
    Hochstrasser, Denis
    Veuthey, Jean-Luc
    CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2011, 49 (07) : 1091 - 1103
12345