Effect of lithium hydroxybutyrate on circadian rhythms of brain serotonin content and plasma corticosteroids in reserpine-treated mice

被引：0

作者：

Zamoshchina, TA

Saratikov, AS

Lishmanov, YB

机构：

[1] Tomsk State Univ, Dept Human & Anim Physiol, Tomsk 634050, Russia

[2] Siberian Med Univ, Dept Pharmacol, Tomsk, Russia

[3] Russian Acad Med Sci, Tomsk Res Ctr, Inst Cardiol, Dept Radionuclide Studies, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1997年 / 124卷 / 07期

关键词：

circadian rhythms; reserpine; serotonin; corticosteroids; lithium hydroxybutyrate;

D O I：

10.1007/BF02445069

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Lithium hydroxybutyrate (10 mg/kg daily for 10 days, intramuscularly) administered in the morning prevents reserpine-induced depression of the diurnal steroidogenesis in mice and the development of desynchronosis between circadian rhythms of serotonin in the blain and plasma corticosteroids. Evening injections result in the formation of phase-discordant 24-h periodicities, the mean values of the studied parameters being unaffected.

引用

页码：709 / 712

页数：4

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