Potential Role of S100A8 in Cutaneous Squamous Cell Carcinoma Differentiation

被引：5

作者：

Shin, Jung-Min ^{[1
]}

Chang, In-Kyu ^{[1
]}

Lee, Young-Ho ^{[2
]}

Yeo, Min-Kyung ^{[3
]}

Kim, Jin-Man ^{[3
]}

Sohn, Kyung-Cheol ^{[1
]}

Im, Myung ^{[1
]}

Seo, Young-Joon ^{[1
]}

Kim, Chang-Deok ^{[1
]}

Lee, Jeung-Hoon ^{[1
]}

Lee, Young ^{[1
]}

机构：

[1] Chungnam Natl Univ, Sch Med, Dept Dermatol, 266 Munhwa Ro, Daejeon, South Korea

[2] Chungnam Natl Univ, Sch Med, Dept Anat, Daejeon, South Korea

[3] Chungnam Natl Univ, Sch Med, Dept Pathol, Daejeon, South Korea

来源：

ANNALS OF DERMATOLOGY | 2016年 / 28卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Actinic keratosis; Differentiation; S100; S100A8; Squamous cell carcinoma; NORMAL COLON MUCOSA; COLORECTAL-CARCINOMA; MATCHED SETS; CANCER; PROGRESSION; EXPRESSION; PROTEINS; SKIN; METASTASIS; MALIGNANCY;

D O I：

10.5021/ad.2016.28.2.179

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Background: S100A8 is differentially expressed in various cell types and is associated with a number of malignant disorders. S100A8 may affect tumor biology. However, its role in cutaneous squamous cell carcinoma (SCC) is not well established. Objective: This study aims to investigate the relationship between S100A8 and cutaneous SCC development. Methods: We performed immunohistochemical staining to detect S100A8 expression in facial skin specimens of pre malignant actinic keratosis (AK), malignant SCC, and normal tissues. In addition, we utilized postconfluence and high calcium-induced differentiation in a culture system model. Furthermore, we constructed a recombinant adenovirus expressing GFP-tagged S100A8 to investigate the role of S100A8 in SCC cell differentiation. Results: S100A8 was significantly overexpressed in human cutaneous SCC compared to that in normal and AK tissues. S100A8 was gradually upregulated in SCC cells in a post-confluence-induced differentiation model. Overexpression of S100A8 in SCC cells induced by adenoviral transduction led to increased expression levels of differentiation markers, such as loricrin, involucrin, and filaggrin. S100A8 overexpression also increased loricrin and involucrin luciferase activity. Conclusion: S100A8 regulates cutaneous SCC differentiation and induces well-differentiated SCC formation in skin.

引用

页码：179 / 185

页数：7

共 33 条

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