Biomimetic iterative method for polyketide synthesis

被引：14

作者：

Akagawa, Kengo ^{[1
]}

Kudo, Kazuaki ^{[1
]}

机构：

[1] Univ Tokyo, Inst Ind Sci, Meguro Ku, 4-6-1 Komaba, Tokyo 1538505, Japan

来源：

CHEMICAL COMMUNICATIONS | 2017年 / 53卷 / 62期

关键词：

ENANTIOSELECTIVE DECARBOXYLATIVE REACTIONS; ACID HALF-THIOESTERS; NATURAL-PRODUCTS; ALDOL REACTIONS; ASSEMBLY-LINE; BIOSYNTHESIS; SYNTHASES; NITROOLEFINS; CONSTRUCTION; MIMICRY;

D O I：

10.1039/c7cc04033d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An iterative method for synthesizing polyketides was demonstrated, in which the chain elongation of a carboxylic acid was performed by decarboxylative dehydration condensation with a malonic acid half thioester. After transforming the resulting beta-ketothioester into an appropriate form, the carboxylic acid functionality was regenerated for the next elongation step.

引用

页码：8645 / 8648

页数：4

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