Optimal management of breast cancer in the elderly patient: current perspectives

被引：25

作者：

Le Saux, Olivia ^{[1
]}

Ripamonti, Bertrand ^{[2
]}

Bruyas, Amandine ^{[3
,4
]}

Bonin, Olivier ^{[4
]}

Freyer, Gilles ^{[1
,4
]}

Bonnefoy, Marc ^{[4
,5
]}

Falandry, Claire ^{[4
,5
]}

机构：

[1] Lyon Sud Univ Hosp, Hosp Civils Lyon, Med Oncol Unit, Pierre Benite, France

[2] Univ Hosp, Gynaecol Obstet Dept, St Etienne, France

[3] Croix Rousse Univ Hosp, Hosp Civils Lyon, Pierre Benite, France

[4] Lyon Univ, Lyon, France

[5] Lyon Sud Univ Hosp, Geriatr Unit, Hosp Civils Lyon, Pierre Benite, France

来源：

CLINICAL INTERVENTIONS IN AGING | 2015年 / 10卷

关键词：

elderly; breast cancer; geriatric assessment; surgery; chemotherapy; radiotherapy; PEGYLATED LIPOSOMAL DOXORUBICIN; COMPREHENSIVE GERIATRIC ASSESSMENT; NO AXILLARY DISSECTION; TARGETED INTRAOPERATIVE RADIOTHERAPY; RANDOMIZED CONTROLLED-TRIAL; ADJUVANT ENDOCRINE THERAPY; PRIMARY SYSTEMIC TREATMENT; LUMPECTOMY PLUS TAMOXIFEN; CONGESTIVE-HEART-FAILURE; PHASE-II MULTICENTER;

D O I：

10.2147/CIA.S50670

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Breast cancer (BC) is the most common female malignancy in the world and almost one third of cases occur after 70 years of age. Optimal management of BC in the elderly is a real challenge and requires a multidisciplinary approach, mainly because the elderly population is heterogeneous. In this review, we describe the various possibilities of treatment for localized or metastatic BC in an aging population. We provide an overview of the comprehensive geriatric assessment, surgery, radiotherapy, and adjuvant therapy for early localized BC and of chemotherapy and targeted therapies for metastatic BC. Finally, we attempt to put into perspective the necessary balance between the expected benefits and risks, especially in the adjuvant setting.

引用

页码：157 / 174

页数：18

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