Lack of Association Between the S83I ParC Mutation in Mycoplasma genitalium and Treatment Outcomes Among Men Who Have Sex With Men with Nongonococcal Urethritis

被引：14

作者：

Chambers, Laura C. ^{[1
]}

Jensen, Jorgen S. ^{[2
]}

Morgan, Jennifer L. ^{[3
]}

Lowens, M. Sylvan ^{[3
]}

Romano, Sarah S. ^{[1
]}

Totten, Patricia A. ^{[4
,5
]}

Soge, Olusegun O. ^{[4
,5
]}

Hughes, James P. ^{[6
]}

Golden, Matthew R. ^{[1
,3
,4
]}

Manhart, Lisa E. ^{[1
,5
]}

机构：

[1] Univ Washington, Dept Epidemiol, 325 Ninth Ave,HMC 359931, Seattle, WA 98104 USA

[2] Statens Serum Inst, Copenhagen, Denmark

[3] Univ Washington, HIV STD Program, Publ Hlth Seattle & King Cty, Seattle, WA 98104 USA

[4] Univ Washington, Dept Med, Seattle, WA 98104 USA

[5] Univ Washington, Dept Global Hlth, Seattle, WA 98104 USA

[6] Univ Washington, Dept Biostat, Seattle, WA 98104 USA

来源：

SEXUALLY TRANSMITTED DISEASES | 2019年 / 46卷 / 12期

基金：

美国国家卫生研究院;

关键词：

RESISTANCE-MEDIATING MUTATIONS; MACROLIDE RESISTANCE; FLUOROQUINOLONE RESISTANCE; FAILURE; INFECTIONS; COHORT; GYRA;

D O I：

10.1097/OLQ.0000000000001035

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

From February 2015 to October 2017, among 20 men who have sex with men with Mycoplasma genitalium-associated nongonococcal urethritis, 15% had macrolide resistance and S83I ParC mutations. Azithromycin followed by moxifloxacin cleared Mycoplasma genitalium in 2 of 2 with and 11 of 13 without S83I mutations. Dual failures were cleared after doxycycline. S83I mutations were not associated with moxifloxacin failure.

引用

页码：805 / 809

页数：5

共 30 条

[1]

[Anonymous], SEX TRANSM DIS TREAT

[2] Mycoplasma genitalium Macrolide and Fluoroquinolone Resistance: Prevalence and Risk Factors Among a 2013-2014 Cohort of Patients in Barcelona, Spain [J].

Barberia, Maria-Jesus ;

Fernandez-Huerta, Miguel ;

Jensen, Jorgen-Skov ;

Caballero, Estrella ;

Andreu, Antonia .

SEXUALLY TRANSMITTED DISEASES, 2017, 44 (08) :457-462

[3] Prevalence of Mycoplasma genitalium in different population groups: systematic review and meta-analysis [J].

Baumann, Lukas ;

Cina, Manuel ;

Egli-Gany, Dianne ;

Goutaki, Myrofora ;

Halbeisen, Florian S. ;

Lohrer, Gian-Reto ;

Ali, Hammad ;

Scott, Pippa ;

Low, Nicola .

SEXUALLY TRANSMITTED INFECTIONS, 2018, 94 (04) :254-261

[4] Macrolide Resistance and Azithromycin Failure in a Mycoplasma genitalium-Infected Cohort and Response of Azithromycin Failures to Alternative Antibiotic Regimens [J].

Bissessor, Melanie ;

Tabrizi, Sepehr N. ;

Twin, Jimmy ;

Abdo, Houda ;

Fairley, Christopher K. ;

Chen, Marcus Y. ;

Vodstrcil, Lenka A. ;

Jensen, Jorgen S. ;

Hocking, Jane S. ;

Garland, Suzanne M. ;

Bradshaw, Catriona S. .

CLINICAL INFECTIOUS DISEASES, 2015, 60 (08) :1228-1236

[5] Mycoplasma genitalium Antibiotic Resistance-Mediating Mutations in Canadian Women With or Without Chlamydia Trachomatis Infection [J].

Chernesky, Max A. ;

Jang, Dan ;

Martin, Irene ;

Hoang, Linda M. N. ;

Naidu, Prenilla ;

Levett, Paul N. ;

Wylie, John ;

Rebbapragada, Anu ;

Ratnam, Sam ;

Smieja, Marek ;

Weinbaum, Barbara ;

Getman, Damon .

SEXUALLY TRANSMITTED DISEASES, 2017, 44 (07) :433-435

[6] Macrolide resistance in Mycoplasma genitalium from female sex workers in Belgium [J].

Coorevits, Liselotte ;

Traen, Ans ;

Binge, Luk ;

Descheemaeker, Patrick ;

Boelens, Jerina ;

Reynders, Marijke ;

Padalko, Elizaveta .

JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE, 2018, 12 :149-152

[7] Mycoplasma genitalium: high prevalence of resistance to macrolides and frequent anorectal infection in men who have sex with men in western Sydney [J].

Couldwell, Deborah L. ;

Jalocon, Dean ;

Power, Melissa ;

Jeoffreys, Neisha J. ;

Chen, Sharon C-A ;

Lewis, David A. .

SEXUALLY TRANSMITTED INFECTIONS, 2018, 94 (06) :406-410

[8] Failure of moxifloxacin treatment in Mycoplasma genitalium infections due to macrolide and fluoroquinolone resistance [J].

Couldwell, Deborah L. ;

Tagg, Kaitlin A. ;

Jeoffreys, Neisha J. ;

Gilbert, Gwendolyn L. .

INTERNATIONAL JOURNAL OF STD & AIDS, 2013, 24 (10) :822-828

[9] Analysis of the gyrA and parC genes of Mycoplasma genitalium detected in first-pass urine of men with non-gonococcal urethritis before and after fluoroquinolone treatment [J].

Deguchi, T ;

Maeda, SI ;

Tamaki, M ;

Yoshida, T ;

Ishiko, H ;

Ito, M ;

Yokoi, S ;

Takahashi, Y ;

Ishihara, S .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2001, 48 (05) :742-744

[10] Emergence of Mycoplasma genitalium with clinically significant fluoroquinolone resistance conferred by amino acid changes both in GyrA and ParC in Japan [J].

Deguchi, Takashi ;

Ito, Shin ;

Yasuda, Mitsuru ;

Kondo, Hiromi ;

Yamada, Yoshiteru ;

Nakane, Keita ;

Mizutani, Kosuke ;

Tsuchiya, Tomohiro ;

Yokoi, Shigeaki ;

Nakano, Masahiro .

JOURNAL OF INFECTION AND CHEMOTHERAPY, 2017, 23 (09) :648-650

← 1 2 3 →