miR-29 family: A potential therapeutic target for cardiovascular disease

被引：46

作者：

Liu, Meng-Nan ^{[1
,2
,3
,4
]}

Luo, Gang ^{[3
,4
]}

Gao, Wan-Jiao ^{[1
,2
]}

Yang, Si-Jin ^{[1
,2
,3
,4
]}

Zhou, Hua ^{[1
,2
]}

机构：

[1] Macau Univ Sci & Technol, Fac Chinese Med, Taipa, Macao, Peoples R China

[2] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China

[3] Southwest Med Univ, Hosp TCM, Natl Tradit Chinese Med Clin Res Base, Luzhou, Sichuan, Peoples R China

[4] Southwest Med Univ, Hosp TCM, Dept Cardiovasc Med, Luzhou, Sichuan, Peoples R China

来源：

PHARMACOLOGICAL RESEARCH | 2021年 / 166卷

基金：

中国国家自然科学基金;

关键词：

MicroRNA; MiR-29; family; Cardiovascular disease; Myocardial fibrosis; Therapeutic target; PULMONARY ARTERIAL-HYPERTENSION; ATRIAL-FIBRILLATION; MICRORNA EXPRESSION; CARDIAC FIBROSIS; HEART-FAILURE; ASSOCIATION; MECHANISMS; PATHOPHYSIOLOGY; CONTRIBUTES; GENOMICS;

D O I：

10.1016/j.phrs.2021.105510

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cardiovascular disease (CVD), including heart failure, myocardial fibrosis and myocardial infarction, etc, remains one of the leading causes of mortality worldwide. Evidence shows that miRNA plays an important role in the pathogenesis of CVD. miR-29 family is one of miRNA, and over the past decades, many studies have demonstrated that miR-29 is involved in maintaining the integrity of arteries and in the regulation of atherosclerosis, especially in the process of myocardial fibrosis. Besides, heart failure, myocardial fibrosis and myocardial infarction are inseparable from the regulatory role of miR-29. Here, we comprehensively review recent studies regarding miR-29 and CVD, illustrate the possibility of miR-29 as a potential marker for prevention, treatment and prognostic observation.

引用

页数：7

共 97 条

[41] Ovine Models of Congenital Heart Disease and the Consequences of Hemodynamic Alterations for Pulmonary Artery Remodeling [J].

Kameny, Rebecca Johnson ;

Datar, Sanjeev A. ;

Boehme, Jason B. ;

Morris, Catherine ;

Zhu, Terry ;

Goudy, Brian D. ;

Johnson, Eric G. ;

Galambos, Csaba ;

Raff, Gary W. ;

Sun, Xutong ;

Wang, Ting ;

Chiacchia, Samuel R. ;

Lu, Qing ;

Black, Stephen M. ;

Maltepe, Emin ;

Fineman, Jeffrey R. .

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2019, 60 (05) :503-514

[42] MicroRNA biogenesis and regulation of bone remodeling [J].

Kapinas, Kristina ;

Delany, Anne M. .

ARTHRITIS RESEARCH & THERAPY, 2011, 13 (03)

[43] The pathogenesis of cardiac fibrosis [J].

Kong, Ping ;

Christia, Panagiota ;

Frangogiannis, Nikolaos G. .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2014, 71 (04) :549-574

[44] The miR-29 family: genomics, cell biology, and relevance to renal and cardiovascular injury [J].

Kriegel, Alison J. ;

Liu, Yong ;

Fang, Yi ;

Ding, Xiaoqiang ;

Liang, Mingyu .

PHYSIOLOGICAL GENOMICS, 2012, 44 (04) :237-244

[45] Identification of novel genes coding for small expressed RNAs [J].

Lagos-Quintana, M ;

Rauhut, R ;

Lendeckel, W ;

Tuschl, T .

SCIENCE, 2001, 294 (5543) :853-858

[46] Developing a panel of biomarkers and miRNA in patients with myocardial infarction for early intervention strategies of heart failure in West Virginian population [J].

Lakhani, Hari Vishal ;

Khanal, Tilak ;

Gabi, Alaa ;

Yousef, George ;

Alam, Mian Bilal ;

Sharma, Dana ;

Aljoudi, Haytham ;

Puri, Nitin ;

Thompson, Ellen ;

Shapiro, Joseph, I ;

Sodhi, Komal .

PLOS ONE, 2018, 13 (10)

[47] A mammalian microRNA expression atlas based on small RNA library sequencing [J].

Landgraf, Pablo ;

Rusu, Mirabela ;

Sheridan, Robert ;

Sewer, Alain ;

Iovino, Nicola ;

Aravin, Alexei ;

Pfeffer, Sebastien ;

Rice, Amanda ;

Kamphorst, Alice O. ;

Landthaler, Markus ;

Lin, Carolina ;

Socci, Nicholas D. ;

Hermida, Leandro ;

Fulci, Valerio ;

Chiaretti, Sabina ;

Foa, Robin ;

Schliwka, Julia ;

Fuchs, Uta ;

Novosel, Astrid ;

Mueller, Roman-Ulrich ;

Schermer, Bernhard ;

Bissels, Ute ;

Inman, Jason ;

Phan, Quang ;

Chien, Minchen ;

Weir, David B. ;

Choksi, Ruchi ;

De Vita, Gabriella ;

Frezzetti, Daniela ;

Trompeter, Hans-Ingo ;

Hornung, Veit ;

Teng, Grace ;

Hartmann, Gunther ;

Palkovits, Miklos ;

Di Lauro, Robert ;

Wernet, Peter ;

Macino, Giuseppe ;

Rogler, Charles E. ;

Nagle, James W. ;

Ju, Jingyue ;

Papavasiliou, F. Nina ;

Benzing, Thomas ;

Lichter, Peter ;

Tam, Wayne ;

Brownstein, Michael J. ;

Bosio, Andreas ;

Borkhardt, Arndt ;

Russo, James J. ;

Sander, Chris ;

Zavolan, Mihaela .

CELL, 2007, 129 (07) :1401-1414

[48] Reducing the Global Burden of Cardiovascular Disease, Part 2 Prevention and Treatment of Cardiovascular Disease [J].

Leong, Darryl P. ;

Joseph, Philip G. ;

McKee, Martin ;

Anand, Sonia S. ;

Teo, Koon K. ;

Schwalm, Jon-David ;

Yusuf, Salim .

CIRCULATION RESEARCH, 2017, 121 (06) :695-710

[49] MicroRNA-29 regulates myocardial microvascular endothelial cells proliferation and migration in association with IGF1 in type 2 diabetes [J].

Li, Zhenjie ;

Jiang, Runxia ;

Yue, Qingcai ;

Peng, Haiying .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2017, 487 (01) :15-21

[50] A microRNA profile comparison between thoracic aortic dissection and normal thoracic aorta indicates the potential role of microRNAs in contributing to thoracic aortic dissection pathogenesis [J].

Liao, Mingfang ;

Zou, Sili ;

Weng, Jianfeng ;

Hon, Lewei ;

Yang, Lin ;

Zhao, Zhiqing ;

Bao, Junmin ;

Jing, Zaiping .

JOURNAL OF VASCULAR SURGERY, 2011, 53 (05) :1341-1349

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