miR-29 family: A potential therapeutic target for cardiovascular disease

被引：46
作者：
Liu, Meng-Nan [1 ,2 ,3 ,4 ]
Luo, Gang [3 ,4 ]
Gao, Wan-Jiao [1 ,2 ]
Yang, Si-Jin [1 ,2 ,3 ,4 ]
Zhou, Hua [1 ,2 ]
机构：
[1] Macau Univ Sci & Technol, Fac Chinese Med, Taipa, Macao, Peoples R China
[2] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China
[3] Southwest Med Univ, Hosp TCM, Natl Tradit Chinese Med Clin Res Base, Luzhou, Sichuan, Peoples R China
[4] Southwest Med Univ, Hosp TCM, Dept Cardiovasc Med, Luzhou, Sichuan, Peoples R China
来源：
PHARMACOLOGICAL RESEARCH | 2021年 / 166卷
基金：
中国国家自然科学基金;
关键词：
MicroRNA; MiR-29; family; Cardiovascular disease; Myocardial fibrosis; Therapeutic target; PULMONARY ARTERIAL-HYPERTENSION; ATRIAL-FIBRILLATION; MICRORNA EXPRESSION; CARDIAC FIBROSIS; HEART-FAILURE; ASSOCIATION; MECHANISMS; PATHOPHYSIOLOGY; CONTRIBUTES; GENOMICS;
D O I：
10.1016/j.phrs.2021.105510
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Cardiovascular disease (CVD), including heart failure, myocardial fibrosis and myocardial infarction, etc, remains one of the leading causes of mortality worldwide. Evidence shows that miRNA plays an important role in the pathogenesis of CVD. miR-29 family is one of miRNA, and over the past decades, many studies have demonstrated that miR-29 is involved in maintaining the integrity of arteries and in the regulation of atherosclerosis, especially in the process of myocardial fibrosis. Besides, heart failure, myocardial fibrosis and myocardial infarction are inseparable from the regulatory role of miR-29. Here, we comprehensively review recent studies regarding miR-29 and CVD, illustrate the possibility of miR-29 as a potential marker for prevention, treatment and prognostic observation.
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页数：7
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