High Affinity Carnitine Transporters from OCTN Family in Neural Cells

被引：22

作者：

Januszewicz, Elzbieta ^{[1
]}

Bekisz, Marek ^{[1
]}

Mozrzymas, Jerzy W. ^{[2
]}

Nalecz, Katarzyna A. ^{[1
]}

机构：

[1] M Nencki Inst Expt Biol, PL-02093 Warsaw, Poland

[2] Wroclaw Med Univ, PL-50367 Wroclaw, Poland

来源：

NEUROCHEMICAL RESEARCH | 2010年 / 35卷 / 05期

关键词：

Carnitine; OCTN transporters; Neurons; Cerebral cortex; Neuroblastoma; ORGANIC CATION/CARNITINE TRANSPORTER; ACID; METABOLISM; ACYLTRANSFERASES; EXPRESSION; NEURONS;

D O I：

10.1007/s11064-010-0131-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Neurons are known to accumulate l-carnitine-a compound necessary for transfer of acyl moieties through biological membranes, apart from very low beta-oxidation of fatty acids in adult brain. Present study demonstrates expression of octn2 and octn3 genes coding high affinity carnitine transporters, as well as presence of both proteins in neurons obtained from suckling and adult rats, and also in mouse transformed neural cells. Measurements of carnitine transport show activity of both transporters in neural cells, pointing to their importance in physiological processes other than beta-oxidation.

引用

页码：743 / 748

页数：6

共 35 条

[1] Immunoglobulins from motoneurone disease patients enhance glutamate release from rat hippocampal neurones in culture [J].

Andjus, PR ;

StevicMarinkovic, Z ;

Cherubini, E .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 504 (01) :103-112

[2]

ARDUINI A, 1992, J BIOL CHEM, V267, P12673

[3]

ARDUINI A, 1994, J NEUROCHEM, V62, P1530

[4] Isolation and culture of adult neurons and neurospheres [J].

Brewer, Gregory J. ;

Torricelli, John R. .

NATURE PROTOCOLS, 2007, 2 (06) :1490-1498

[5]

Ebert D, 2003, J NEUROSCI, V23, P5928

[6] β-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter [J].

Ganapathy, ME ;

Huang, W ;

Rajan, DP ;

Carter, AL ;

Sugawara, M ;

Iseki, K ;

Leibach, FH ;

Ganapathy, V .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (03) :1699-1707

[7] Discovery of the ergothioneine transporter [J].

Gründemann, D ;

Harlfinger, S ;

Golz, S ;

Geerts, A ;

Lazar, A ;

Berkels, R ;

Jung, N ;

Rubbert, A ;

Schömig, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (14) :5256-5261

[8] L-CARNITINE UPTAKE BY MOUSE-BRAIN SYNAPTOSOMAL PREPARATIONS - COMPETITIVE-INHIBITION BY GABA [J].

HANNUNIEMI, R ;

KONTRO, P .

NEUROCHEMICAL RESEARCH, 1988, 13 (04) :317-323

[9] Functional expression of the organic cation/carnitine transporter 2 in rat astrocytes [J].

Inazu, M ;

Takeda, H ;

Maehara, K ;

Miyashita, K ;

Tomoda, A ;

Matsumiya, T .

JOURNAL OF NEUROCHEMISTRY, 2006, 97 (02) :424-434

[10] Organic cation/carnitine transporter OCTN3 is present in astrocytes and is up-regulated by peroxisome proliferators-activator receptor agonist [J].

Januszewicz, Elzbieta ;

Pajak, Beata ;

Gajkowska, Barbara ;

Samluk, Lukasz ;

Djavadian, Rouzanna L. ;

Hinton, Barry T. ;

Nalecz, Katarzyna A. .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2009, 41 (12) :2599-2609

← 1 2 3 4 →