Time-resolved crystallography using the Hadamard transform

被引：0
|
作者：
Yorke, Briony A. [1 ]
Beddard, Godfrey S. [2 ]
Owen, Robin L. [3 ]
Pearson, Arwen R. [1 ]
机构：
[1] Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds, W Yorkshire, England
[2] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England
[3] Harwell Sci & Innovat Campus, Didcot, Oxon, England
来源：
NATURE METHODS | 2014年 / 11卷 / 11期
基金：
英国工程与自然科学研究理事会; 英国生物技术与生命科学研究理事会; 英国惠康基金;
关键词：
PROTEIN; DIFFRACTION;
D O I：
10.1038/NMETH.3139
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
We describe a method for performing time-resolved X-ray crystallographic experiments based on the Hadamard transform, in which time resolution is defined by the underlying periodicity of the probe pulse sequence, and signal/noise is greatly improved over that for the fastest pump-probe experiments depending on a single pulse. This approach should be applicable on standard synchrotron beamlines and will enable high-resolution measurements of protein and small-molecule structural dynamics. It is also applicable to other time-resolved measurements where a probe can be encoded, such as pump-probe spectroscopy.
引用
收藏
页码：1131 / 1134
页数：4
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