Primate-specific Long Non-coding RNAs and MicroRNAs

被引：59

作者：

Awan, Hassaan Mehboob ^{[1
]}

Shah, Abdullah ^{[1
]}

Rashid, Farooq ^{[1
]}

Shan, Ge ^{[1
]}

机构：

[1] Univ Sci & Technol China, CAS Key Lab Innate Immun & Chron Dis, CAS Ctr Excellence Mol Cell Sci, Sch Life Sci, Hefei 230027, Peoples R China

来源：

GENOMICS PROTEOMICS & BIOINFORMATICS | 2017年 / 15卷 / 03期

基金：

中国国家自然科学基金;

关键词：

RAPID EVOLUTION; CIRCULAR RNAS; HUMAN CANCER; GENE; EXPRESSION; TRANSCRIPTION; PROTEIN; ORIGIN; ROLES; IDENTIFICATION;

D O I：

10.1016/j.gpb.2017.04.002

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Non-coding RNAs (ncRNAs) are critical regulators of gene expression in essentially all life forms. Long ncRNAs (lncRNAs) and microRNAs (miRNAs) are two important RNA classes possessing regulatory functions. Up to date, many primate-specific ncRNAs have been identified and investigated. Their expression specificity to primate lineage suggests primate-specific roles. It is thus critical to elucidate the biological significance of primate or even human-specific ncRNAs, and to develop potential ncRNA-based therapeutics. Here, we have summarized the studies regarding regulatory roles of some key primate-specific lncRNAs and miRNAs.

引用

页码：187 / 195

页数：9

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