Synthesis of derivatives of pyrido[3′,2′-:4,5]furo[3,2-c]isoquinoline heterocyclic system

An approach to the synthesis of derivatives of new heterocyclic system, pyrido[3 ',2 ':4,51furo[3,2-clisoquinoline, was suggested. A condensation reaction of substituted 3-cyanopyridin2(111)-ones with methyl 2-(chloromethyl)benzoate and subsequent treatment of the condensation product with potassium tert-butoxide leads to substituted pyrido [3 ',2 ':4,51furo [3,2-c]-isoquinolin-5(61/)-ones. Similarly, a condensation reaction of substituted 3-cyanopyridin2(111)-ones with 2-(chloromethypbenzonitrile and subsequent treatment of the condensation product with potassium tert-butoxide gives substituted 5-aminopyrido [3 ',2 ':4,51furo[3,2-c]-isoquinolines.