Cytokeratin positivity in paraffin-embedded malignant melanomas: Comparative study of KL1, A4 and Lu5 antibodies

被引：0

作者：

Korabiowska, M

Fischer, G

Steinacker, A

Stachura, J

Cordon-Cardo, C

Brinck, U

机构：

[1] Univ Gottingen, Dept Cytopathol, D-37075 Gottingen, Germany

[2] Univ Gottingen, Teaching Hosp, Reinhard Neiter Hosp, Dept Pathol, Wilhelmshaven, Germany

[3] Jagiellonian Univ, Dept Pathol, PL-50351 Krakow, Poland

[4] Mem Sloan Kettering Canc Ctr, Div Mol Pathol, New York, NY 10021 USA

来源：

ANTICANCER RESEARCH | 2004年 / 24卷 / 5B期

关键词：

malignant melanoma; cytokeratin;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The unclear role of cytokeratin (CK) in the progression and diagnostics of malignant melanomas stimulated us to compare the reactivity of three antibodies directed to CK in 109 paraffin-embedded melanomas. By far the majority of melanomas did not express cytokeratin even at the <1% level, only vimentin. In about 6% of melanomas it was possible to find CK expression ranging between 3 and 40% of melanoma cells. There was a correlation between CK expression and pT-stage. Cytokeratin-expressing tumours were found in the more advanced pT-stages. The independent prognostic values of none of the three CK antibodies investigated could be shown.

引用

页码：3203 / 3207

页数：5