Impairment of fronto-striatal and parietal cerebral networks correlates with attention deficit hyperactivity disorder (ADHD) psychopathology in adults A functional magnetic resonance imaging (fMRI) study

被引:113
作者
Schneider, Marc F. [1 ]
Krick, Christoph M. [2 ]
Retz, Wolfgang [1 ]
Hengesch, Georges [1 ]
Retz-Junginger, Petra [1 ]
Reith, Wolfgang [2 ]
Roesler, Michael [1 ]
机构
[1] Saarland Univ Hosp, Neuroctr, Inst Forens Psychol & Psychiat, D-66421 Homburg, Germany
[2] Saarland Univ Hosp, Neuroctr, Dept Neuroradiol, Homburg, Germany
关键词
Attention deficit hyperactivity disorder (ADHD); Functional magnetic resonance imaging (fMRI); Attention networks; Continuous performance test (CPT); Adult; CONTINUOUS PERFORMANCE TASK; EVENT-RELATED FMRI; DEFICIT/HYPERACTIVITY DISORDER; DOPAMINE TRANSPORTER; REWARD ANTICIPATION; GLUCOSE-METABOLISM; PREFRONTAL CORTEX; INTERFERENCE TASK; NEURAL RESPONSES; DECISION-MAKING;
D O I
10.1016/j.pscychresns.2010.04.005
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Attention deficit hyperactivity disorder (ADHD) is a common, genetically transmitted common childhood-onset disorder with a high rate of persistence in adulthood. Although many studies have shown anatomical and functional abnormalities in children and adolescents, studies with adult patients are rare. Nineteen adults with ADHD (11 ADHD, combined type; 8 ADHD, partially remitted) and 17 controls were included in this functional magnetic resonance imaging (fMRI) study. Brain activation was investigated with a continuous performance test (CPT). Impaired activation of a fronto-striatal and a parietal attentional network was observed during the NoGo condition in ADHD subjects. Correlations of reduced activity of the caudate nuclei, the anterior cingulate cortex, and parietal cortical structures, as well as increased activity in the insular cortex, with inattention and impulsivity symptom scores were found. The activation patterns were similar to those known from children and adolescents with ADHD. In conclusion we found not only a widespread dysfunction of brain regions that are involved in cognitive processing in adults with ADHD compared with controls, but also correlations between symptom severity and dysfunction of neuronal systems across adult subjects with a history of ADHD in childhood but whose symptoms did (persistent ADHD) and did not (not persistent ADHD) qualify for a full diagnosis of ADHD in adulthood. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:75 / 84
页数:10
相关论文
共 72 条
  • [1] [Anonymous], 1997, ADHD and the Nature of Self-Control
  • [2] [Anonymous], 1997, Interviewheft und Beurteilungsheft. Eine deutschsprachige
  • [3] Barkley RA, 2002, J CLIN PSYCHIAT, V63, P10
  • [4] Age-dependent decline of symptoms of attention deficit hyperactivity disorder: Impact of remission definition and symptom type
    Biederman, J
    Mick, E
    Faraone, SV
    [J]. AMERICAN JOURNAL OF PSYCHIATRY, 2000, 157 (05) : 816 - 818
  • [5] Larger deficits in brain networks for response inhibition than for visual selective attention in attention deficit hyperactivity disorder (ADHD)
    Booth, JR
    Burman, DD
    Meyer, JR
    Lei, Z
    Trommer, BL
    Davenport, ND
    Li, W
    Parrish, TB
    Gitelman, DR
    Mesulam, MM
    [J]. JOURNAL OF CHILD PSYCHOLOGY AND PSYCHIATRY, 2005, 46 (01) : 94 - 111
  • [6] Bush G, 1998, HUM BRAIN MAPP, V6, P270, DOI 10.1002/(SICI)1097-0193(1998)6:4<270::AID-HBM6>3.0.CO
  • [7] 2-0
  • [8] Anterior cingulate cortex dysfunction in attention-deficit/hyperactivity disorder revealed by fMRI and the counting stroop
    Bush, G
    Frazier, JA
    Rauch, SL
    Seidman, LJ
    Whalen, PJ
    Jenike, MA
    Rosen, BR
    Biederman, J
    [J]. BIOLOGICAL PSYCHIATRY, 1999, 45 (12) : 1542 - 1552
  • [9] Functional magnetic resonance imaging of methylphenidate and placebo in attention-deficit/hyperactivity disorder during the multi-source interference task
    Bush, George
    Spencer, Thomas J.
    Holmes, Jennifer
    Shin, Lisa M.
    Valera, Eve M.
    Seidman, Larry J.
    Makris, Nikos
    Surman, Craig
    Aleardi, Megan
    Mick, Eric
    Biederman, Joseph
    [J]. ARCHIVES OF GENERAL PSYCHIATRY, 2008, 65 (01) : 102 - 114
  • [10] Dissociable effects of cingulate and medial frontal cortex lesions on stimulus-reward learning using a novel Pavlovian autoshaping procedure for the rat: Implications for the neurobiology of emotion
    Bussey, TJ
    Everitt, BJ
    Robbins, TW
    [J]. BEHAVIORAL NEUROSCIENCE, 1997, 111 (05) : 908 - 919