Retinoblastoma: the disease, gene and protein provide critical leads to understand cancer

被引：92
作者：
DiCiommo, D
Gallie, BL
Bremner, R
机构：
[1] Univ Toronto, Dept Ophthalmol, Toronto, ON MST 258, Canada
[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON MST 258, Canada
[3] Univ Toronto, Dept Med Biophys, Toronto, ON MST 258, Canada
[4] Univ Toronto, Dept Lab Med & Pathobiol, Toronto, ON MST 258, Canada
[5] Ontario Canc Inst, Toronto, ON MST 258, Canada
[6] Hosp Sick Children, Toronto, ON MST 258, Canada
[7] Toronto Western Res Inst, Toronto, ON MST 258, Canada
来源：
SEMINARS IN CANCER BIOLOGY | 2000年 / 10卷 / 04期
关键词：
retinoblastoma; cancer; tumor suppressor; mutation identification;
D O I：
10.1006/scbi.2000.0326
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Retinoblastoma has contributed much to the understanding of cancer. The protein product of the RB gene, pRB, is a multifaceted regulator of transcription which controls the cell cycle, differentiation and apoptosis in normal development of specific tissues. Elucidating the mechanisms in which pRB plays a critical role will enable novel therapies and strategies for prevention, not only for retinoblastoma, but for cancer in general.
引用
收藏
页码：255 / 269
页数：15
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