Narrowband ultraviolet B phototherapy in combination with other therapies for vitiligo: mechanisms and efficacies

被引：26
作者：
Abyaneh, M. Yazdani [1 ]
Griffith, R. D. [1 ]
Falto-Aizpurua, L. [1 ]
Nouri, K. [1 ]
机构：
[1] Univ Miami, Leonard M Miller Sch Med, Dept Dermatol & Cutaneous Surg, Miami, FL 33136 USA
来源：
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2014年 / 28卷 / 12期
关键词：
CALCINEURIN INHIBITORS DECREASE; NON-SEGMENTAL VITILIGO; TOPICAL CALCIPOTRIOL; UVB PHOTOTHERAPY; TACROLIMUS OINTMENT; VITAMIN-D; REPIGMENTATION THERAPIES; NONSEGMENTAL VITILIGO; HUMAN KERATINOCYTES; MESSENGER-RNA;
D O I：
10.1111/jdv.12619
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Vitiligo is a disorder of pigmentation affecting about 1% of the global population. It is a psychologically devastating disease with suboptimal treatment options. Narrowband ultraviolet B (NB-UVB) phototherapy has become a first-line choice for treating generalized disease. In recent years, topical calcineurin inhibitors, vitamin D analogues, antioxidant agents and other therapies have been combined with NB-UVB to improve its efficacy. This article will address what is known about the mechanisms of action of these treatments and how they may complement NB-UVB on a cellular level, as well as offer a comprehensive, evidence-based review of clinical outcomes with combination therapies.
引用
收藏
页码：1610 / 1622
页数：13
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