Task-induced deactivation of midline cortical regions in schizophrenia assessed with fMRI

被引：138

作者：

Harrison, Ben J.

Yucel, Murat

Pujol, Jesus

Pantelis, Christos

机构：

[1] Univ Melbourne, Dept Psychiat, Melbourne Neuropsychiat Ctr, Natl Neurosci Facil, Melbourne, Vic, Australia

[2] ORYGEN Res Ctr, Melbourne, Vic, Australia

[3] Univ Melbourne, Howard Florey Inst Expt Physiol & Med, Melbourne, Vic, Australia

[4] CRC Corp Sanitaria, Inst Alta Tecnol PRBB, Barcelona, Spain

来源：

SCHIZOPHRENIA RESEARCH | 2007年 / 91卷 / 1-3期

基金：

英国医学研究理事会;

关键词：

fMRI; schizophrenia; task-induced deactivations; emotional awareness; cingulate; medial prefrontal; default mode activity; DEFAULT-MODE; SELF-AWARENESS; ALEXITHYMIA; BRAIN; RECOGNITION; INSIGHT; MIND;

D O I：

10.1016/j.schres.2006.12.027

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Task-induced deactivations (TIDs) of midline cortical regions are readily observed in fMRI studies and may reflect elements of a 'default-mode' of brain function associated with self-directed mental processes at rest. In this study, we examined this TID phenomenon in schizophrenia and its relevance to patients' symptoms, task performance and level of emotional awareness. Relative to control subjects, patients showed significantly greater TID of the rostral anterior cingulate (rAC)/medial prefrontal cortex (mPFC) and precuneus (PrC)/posterior cingulate cortex (PC). The magnitude of prefrontal TIDs was associated with patients' task performance and emotional awareness for others. The nature of these associations suggests a complex interchange between cognitive and emotional influences on the resting-state activity of these prefrontal `default mode' regions in schizophrenia. (c) 2007 Elsevier B.V. All rights reserved.

引用

页码：82 / 86

页数：5

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