Structural and Functional Properties of the C-terminal Region of Mitochondrial ADP/ATP Carrier

被引：1

作者：

Shinohara, Yasuo ^{[1
,3
]}

Hashimoto, Mitsuru ^{[4
]}

Kihira, Yoshitaka ^{[2
]}

Ohkura, Kazuto ^{[5
]}

Majima, Eiji ^{[6
]}

Terada, Hiroshi ^{[7
]}

机构：

[1] Univ Tokushima, Inst Genome Res, Tokushima 7708503, Japan

[2] Univ Tokushima, Inst Hlth Biosci, Tokushima 7708503, Japan

[3] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan

[4] Matsuyama Univ, Fac Pharmaceut Sci, Matsuyama, Ehime 7908578, Japan

[5] Chiba Inst Sci, Fac Pharm, Choshi 2880025, Japan

[6] Protenova Inc, Takamatsu, Kagawa 7610301, Japan

[7] Tokyo Univ Sci, Fac Pharmaceut Sci, Noda, Chiba 2788510, Japan

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 2010年 / 130卷 / 02期

关键词：

ADP/ATP carrier (AAC); solute carrier family; mitochondria; transport mechanism; yeast; SITE-DIRECTED MUTAGENESIS; YEAST; EXPRESSION; ADP;

D O I：

10.1248/yakushi.130.199

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mitochondrial ADP/ATP carrier (AAC) is a protein catalyzing the transport of adenine nucleotides across inner mitochondrial membrane. In this review article, we first briefly introduce structural and functional properties of this protein. Next, we describe the results of our recent studies on the difference in the C-terminal region between yeast type 2 AAC isoform and bovine type 1 AAC isoform. Furthermore, based on the reactivities of cysteine residues that replaced amino acids in the sixth transmembrane segment, the probable structural features of the C-terminal region of this carrier are discussed.

引用

页码：199 / 204

页数：6

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