The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention

被引:948
作者
Holick, Michael F. [1 ]
机构
[1] Boston Univ, Med Ctr, Dept Med, Endocrinol Nutr & Diabet, Boston, MA 02118 USA
关键词
Vitamin D deficiency; Vitamin D insufficiency; Sunlight; Rickets; Vitamin D-2; Vitamin D-3; 25-hydroxyvitamin D; Vitamin D toxicity; 25-HYDROXYVITAMIN D CONCENTRATIONS; HYPOVITAMINOSIS-D; D SUPPLEMENTATION; SUN EXPOSURE; CARDIOVASCULAR-DISEASE; ULTRAVIOLET-RADIATION; HIGH PREVALENCE; HEALTHY-ADULTS; D INTOXICATION; RISK-FACTOR;
D O I
10.1007/s11154-017-9424-1
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Vitamin D deficiency and insufficiency is a global health issue that afflicts more than one billion children and adults worldwide. The consequences of vitamin D deficiency cannot be under estimated. There has been an association of vitamin D deficiency with a myriad of acute and chronic illnesses including preeclampsia, childhood dental caries, periodontitis, autoimmune disorders, infectious diseases, cardiovascular disease, deadly cancers, type 2 diabetes and neurological disorders. This review is to put into perspective the controversy surrounding the definition for vitamin D deficiency and insufficiency as well as providing guidance for how to treat and prevent vitamin D deficiency.
引用
收藏
页码:153 / 165
页数:13
相关论文
共 94 条
  • [31] Treatment of hypovitaminosis D in infants and toddlers
    Gordon, Catherine M.
    Williams, Avery LeBoff
    Feldman, Henry A.
    May, Jessica
    Sinclair, Linda
    Vasquez, Alex
    Cox, Joanne E.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2008, 93 (07) : 2716 - 2721
  • [32] Do studies reporting 'U'- shaped serum 25-hydroxyvitamin D-health outcome relationships reflect adverse effects?
    Grant, William B.
    Karras, Spyridon N.
    Bischoff-Ferrari, Heike A.
    Annweiler, Cedric
    Boucher, Barbara J.
    Juzeniene, Asta
    Garland, Cedric F.
    Holick, Michael F.
    [J]. DERMATO-ENDOCRINOLOGY, 2016, 8 (01)
  • [33] 25-Hydroxyvitamin D in Canadian adults: biological, environmental, and behavioral correlates
    Greene-Finestone, L. S.
    Berger, C.
    de Groh, M.
    Hanley, D. A.
    Hidiroglou, N.
    Sarafin, K.
    Poliquin, S.
    Krieger, J.
    Richards, J. B.
    Goltzman, D.
    [J]. OSTEOPOROSIS INTERNATIONAL, 2011, 22 (05) : 1389 - 1399
  • [34] All-Source Basal Vitamin D Inputs Are Greater Than Previously Thought and Cutaneous Inputs Are Smaller
    Heaney, Robert P.
    Armas, Laura A. G.
    French, Christine
    [J]. JOURNAL OF NUTRITION, 2013, 143 (05) : 571 - 575
  • [35] Vitamin D3 Is More Potent Than Vitamin D2 in Humans
    Heaney, Robert P.
    Recker, Robert R.
    Grote, James
    Horst, Ronald L.
    Armas, Laura A. G.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2011, 96 (03) : E447 - E452
  • [36] Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol
    Heaney, RP
    Davies, KM
    Chen, TC
    Holick, MF
    Barger-Lux, MJ
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 2003, 77 (01) : 204 - 210
  • [37] Heaney RP, 2011, J CLIN ENDOCR METAB, V152, P741, DOI DOI 10.1210/endo.152.2.zee741a
  • [38] Can you have your cake and eat it too? The sunlight D-lema
    Holick, M. F.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2016, 175 (06) : 1129 - 1131
  • [39] Prevalence of vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy
    Holick, MF
    Siris, ES
    Binkley, N
    Beard, MK
    Khan, A
    Katzer, JT
    Petruschke, RA
    Chen, EL
    de Papp, AE
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (06) : 3215 - 3224
  • [40] Holick MF, 2008, AM J CLIN NUTR, V87, p1080S