Protein complexes and proteome organization from yeast to man

被引：95
作者：
Gavin, AC [1 ]
Superti-Furga, G [1 ]
机构：
[1] Cellzome AG, D-69117 Heidelberg, Germany
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 2003年 / 7卷 / 01期
关键词：
D O I：
10.1016/S1367-5931(02)00007-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein complexes may well be the most relevant molecular units of cellular function. The activities of protein complexes have to be regulated both in time and space to integrate within the overall cell programs. The cell can be compared to a factory orchestrating individual assembly lines into integrated networks fulfilling particular and superimposed tasks. Recent proteome-wide studies provide insight into the properties of cellular protein complexes, their modular nature, their interaction with other complexes and the resulting preliminary organization chart of the proteome.
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页码：21 / 27
页数：7
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