Proanthocyanidins in health and disease

被引：108
作者：
Blade, Cinta [1 ]
Aragones, Gerard [1 ]
Arola-Arnal, Anna [1 ]
Muguerza, Begona [1 ]
Isabel Bravo, Francisca [1 ]
Josepa Salvado, M. [1 ]
Arola, Lluis [1 ]
Suarez, Manuel [1 ]
机构：
[1] Univ Rovira & Virgili, Dept Biochem & Biotechnol, Nutrigen Res Grp, E-43007 Tarragona, Spain
来源：
BIOFACTORS | 2016年 / 42卷 / 01期
关键词：
polyphenols; flavonoids; molecular mechanisms; metabolic diseases; microbiota; circadian rhythms; GRAPE SEED EXTRACT; DIETARY PROANTHOCYANIDINS; PROSPECTIVE COHORT; NITRIC-OXIDE; IN-VITRO; MOLECULAR-MECHANISMS; FLAVONOID INTAKE; BLOOD-PRESSURE; HEPG2; CELLS; PROCYANIDINS;
D O I：
10.1002/biof.1249
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Proanthocyanidins (PAs) are the most abundant flavonoids in the human diet. Several epidemiological studies connect PA consumption and health benefits and the designation of PAs as healthy compounds started at the early stages of the 20th century. The beneficial health properties of PAs are attributed to their conjugated and colonic metabolites. Therefore, gut microbial compositions can determine the effectiveness of PAs. Reciprocally, dietary polyphenols can act as prebiotics. Recently, it has also been described that PAs modulate the circadian rhythm. Biochemical and epigenetic mechanisms, including the modulation of microRNAs, allow PAs to modulate cell functionality. PA effects in metabolic diseases are also reviewed. (c) 2016 BioFactors, 42(1):5-12, 2016
引用
收藏
页码：5 / 12
页数：8
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