Acid-base regulation of angiotensin receptors in the kidney

被引:5
|
作者
Nagami, Glenn T. [1 ,2 ,3 ,4 ]
Kraut, Jeffrey A. [1 ,2 ,3 ,4 ,5 ]
机构
[1] VA Greater Los Angeles Healthcare Syst, Nephrol Sect, Los Angeles, CA 90073 USA
[2] VA Greater Los Angeles Healthcare Syst, Nephrol Res Lab, Dept Med, Los Angeles, CA 90073 USA
[3] VA Greater Los Angeles Healthcare Syst, Res Serv, Los Angeles, CA 90073 USA
[4] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA
[5] Univ Calif Los Angeles, David Geffen Sch Med, Membrane Biol Lab, Los Angeles, CA 90095 USA
来源
CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION | 2010年 / 19卷 / 01期
关键词
acidosis; ammonia excretion; nephron; type 1 Ang II receptor; urinary acidification; THICK ASCENDING LIMB; CHRONIC METABOLIC-ACIDOSIS; MEDULLARY COLLECTING DUCT; II-BINDING-SITES; PROXIMAL BICARBONATE ABSORPTION; LATE DISTAL TUBULE; PERFUSED IN-VITRO; H+-K+-ATPASE; AMMONIA PRODUCTION; INTERCALATED CELLS;
D O I
10.1097/MNH.0b013e32833289fd
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
Purpose of review Angiotensin II (Ang II) is a major systemic regulator of blood pressure, blood volume, and acid-base homeostasis. However, the effects of local Ang II signaling in the kidney are less well known. Here we review the impact of Ang II on acid-base transport in specific nephron segments and discuss the recently described role of acid loading in sensitizing the proximal tubule to Ang II. Recent findings Recent studies suggest that Ang II signaling is necessary for a normal kidney response to acid loads. Under acidic conditions, tubule cells upregulate type 1 Ang II receptors, amplifying the effects of Ang II. Site of action may also affect Ang II activity, as Ang II can produce divergent effects when acting on the luminal versus basolateral aspects of tubule cells. High luminal concentrations of Ang II and its precursors may facilitate coordinated acid-base transport and metabolic activity throughout the nephron. Summary Local Ang II signaling in the kidney directly modulates acid-base transport and metabolism, providing an additional mechanism by which the renin-angiotensin-aldosterone system regulates acid-base balance. The segment-specific and acid-stimulated responses of the tubule to Ang II are diverse and merit further exploration for their adaptive and potentially maladaptive roles.
引用
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页码:91 / 97
页数:7
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