Analysis of chloramphenicol in honey by on-line pretreatment liquid chromatography-tandem mass spectrometry

被引：38

作者：

Kawano, Shin-ichi ^{[1
,2
]}

Hao, Hong-Yuan ^{[2
]}

Hashi, Yuki ^{[2
]}

Lin, Jin-Ming ^{[1
]}

机构：

[1] Tsinghua Univ, Dept Chem, Beijing Key Lab Microanalyt Methods & Instrumenta, Beijing 100084, Peoples R China

[2] Shimadzu China Co Ltd, Shimadzu Global COE Applicat & Tech Dev, Shanghai 200052, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2015年 / 26卷 / 01期

基金：

中国国家自然科学基金;

关键词：

On-line pretreatment; Liquid chromatography-mass spectrometry; Chloramphenicol; Honey; DILUTION LINE; DRUGS; PLASMA; SERUM;

D O I：

10.1016/j.cclet.2014.10.026

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chloramphenicol is an antibiotic and one of the potential contaminants in honey. Solid-phase extraction is the key pretreatment procedure for analysis of chloramphenicol in honey. In this work, an on-line pretreatment liquid chromatography-tandem mass spectrometer system for sensitive, reliable and higher throughput analysis was developed. With the methylcellulose-immobilized reversed-phase column, sugars in a honey sample were efficiently removed in 1 min. As a result, the limit of quantitation of chloramphenicol was 20 pg/mL (0.2 mu g/kg honey). (C) 2014 Jin-Ming Lin. Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. All rights reserved.

引用

页码：36 / 38

页数：3

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