PAR-2 expression and lymphocyte proliferative response inhibition by trypsin

被引：0

作者：

Sánchez-Hernández, PE ^{[1
]}

Ramírez-Dueñas, MG ^{[1
]}

Del Toro-Arreola, S ^{[1
]}

Del Toro-Arreola, A ^{[1
]}

Daneri-Navarro, A ^{[1
]}

机构：

[1] Univ Guadalajara, Lab Immunol, Dept Fisiol, Univ Ciencias Salud, Guadalajara 44430, Jalisco, Mexico

来源：

IMMUNOLOGY 2004: GENOMIC ISSUES, IMMUNE SYSTEM ACTIVATION AND ALLERGY | 2004年

关键词：

D O I：

暂无

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Trypsin has been involved in tumor growth and metastasis. These events are partially mediated by PAR-2 activation on tumor cells. The aim of this work is to evaluate lymphocyte PAR-2 expression and the effect of trypsin on lymphocyte proliferation, IL-2Ralpha expression, and cytokine levels. Trypsin inhibited lymphocyte proliferative-response, IL-2Ralpha expression and IL-2, IL-4, IFN-gamma and IL-10 supernatants levels on PHA-stimulated lymphocytes. In contrast, intracellular cytokines positive cells were not diminished by trypsin incubation. Lymphocyte PAR-2 increased upon PHA stimulation. Our results support that inhibition of lymphocyte proliferation may be induced by cytokines and IL-2Ralpha clevage, suggesting that trypsin may contribute to immune evasion, while promoting growth tumor and metastasis.

引用

页码：385 / 390

页数：6

共 6 条

[1] Immunologic mechanisms of antitumor activity [J].