Preparation and Characterization of Methylene Blue-Incorporated Folate-Functionalized Fe3O4/Mesoporous Silica Core/Shell Magnetic Nanoparticles

被引：9

作者：

Zhao, Xueling ^{[1
,2
]}

Zhao, Hongli ^{[1
,2
]}

Chen, Zongyan ^{[1
,2
]}

Zhang, Denghao ^{[1
,2
]}

Lan, Minbo ^{[1
,2
,3
]}

机构：

[1] E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

[2] E China Univ Sci & Technol, Res Ctr Anal & Test, Shanghai 200237, Peoples R China

[3] E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2015年 / 15卷 / 07期

基金：

中国国家自然科学基金;

关键词：

Magnetic Nanoparticle; Mesoporous Silica; Multifunctional; Magnetic Resonance Imaging; Fluorescence Imaging; Drug Delivery; IRON-OXIDE NANOPARTICLES; PHOTODYNAMIC THERAPY; MOLECULAR-DETECTION; DNA HYBRIDIZATION; NUCLEIC-ACIDS; EXTRACTION; DELIVERY; SYSTEM;

D O I：

10.1166/jnn.2015.9867

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In the present work, a multifunctional nanomaterial, methylene blue-incorporated folate-functionalized Fe3O4/mesoporous silica core/shell magnetic nanoparticles, has been developed. Firstly, highly biocompatible monodisperse superparamagnetic Fe3O4@mSiO(2) core/shell nanoparticles with mesoporous silica shells were synthesized. Then these particles were coated with the covalently bonded biocompatible polymer poly(ethylene glycol) (PEG) and modified with the cancer targeting ligand folic acid (FA). Finally, the water-soluble photosensitizer methylene blue (MB) was loaded into the mesoporous silica shell. Systematic experiments were performed to carefully evaluate the physical and chemical properties, cytotoxicity and cellular uptake of the multifunctional nanomaterial.

引用

页码：4976 / 4983

页数：8

共 39 条

[1] Clinical photodynamic therapy of head and neck cancers-A review of applications and outcomes [J].

Allison, R. R. ;

Cuenca, R. E. ;

Downie, G. H. ;

Camnitze, P. ;

Brodish, B. ;

Sibata, C. H. .

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY, 2005, 2 (03) :205-222

[2] The present and future role of photodynamic therapy in cancer treatment [J].

Brown, SB ;

Brown, EA ;

Walker, I .

LANCET ONCOLOGY, 2004, 5 (08) :497-508

[3]

Cao Z. H., 2009, ANGEW CHEM INT EDIT, V121, P6615

[4] Imaging and Photodynamic Therapy: Mechanisms, Monitoring, and Optimization [J].

Celli, Jonathan P. ;

Spring, Bryan Q. ;

Rizvi, Imran ;

Evans, Conor L. ;

Samkoe, Kimberley S. ;

Verma, Sarika ;

Pogue, Brian W. ;

Hasan, Tayyaba .

CHEMICAL REVIEWS, 2010, 110 (05) :2795-2838

[5] Deep Penetration of a PDT Drug into Tumors by Noncovalent Drug-Gold Nanoparticle Conjugates [J].

Cheng, Yu ;

Meyers, Joseph D. ;

Broome, Ann-Marie ;

Kenney, Malcolm E. ;

Basilion, James P. ;

Burda, Clemens .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2011, 133 (08) :2583-2591

[6] Synergistically Integrated Nanoparticles as Multimodal Probes for Nanobiotechnology [J].

Cheon, Jinwoo ;

Lee, Jae-Hyun .

ACCOUNTS OF CHEMICAL RESEARCH, 2008, 41 (12) :1630-1640

[7] Cancer theranostics: the rise of targeted magnetic nanoparticles [J].

Cole, Adam J. ;

Yang, Victor C. ;

David, Allan E. .

TRENDS IN BIOTECHNOLOGY, 2011, 29 (07) :323-332

[8]

Dabestani R, 1999, PHOTOCHEM PHOTOBIOL, V70, P10, DOI 10.1111/j.1751-1097.1999.tb01945.x

[9] Preparation of near-IR fluorescent nanoparticles for fluorescence-anisotropy-based immunoagglutination assay in whole blood [J].

Deng, Ting ;

Li, Ji-Shan ;

Jiang, Jian-Hui ;

Shen, Guo-Li ;

Yu, Ru-Qin .

ADVANCED FUNCTIONAL MATERIALS, 2006, 16 (16) :2147-2155

[10] Surface-Engineered Magnetic Nanoparticles for Molecular Detection of Infectious Agents and Cancer [J].

Elingarami, Sauli ;

Liu, Ming ;

Li, Zhiyang ;

He, Nongyue .

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2013, 13 (05) :3204-3213

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