Construction of a series of intermediates in the β-oxidation pathway from THA to EPA via DHA in free acid form

被引：6

作者：

Kanamori, Satoshi ^{[1
]}

Ishida, Hiroaki ^{[1
]}

Yamamoto, Keiko ^{[1
]}

Itoh, Toshimasa ^{[1
]}

机构：

[1] Showa Pharmaceut Univ, Lab Drug Design & Med Chem, 3-3165 Higashi Tamagawagakuen, Machida, Tokyo 1948543, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2018年 / 26卷 / 15期

关键词：

DOCOSAHEXAENOIC ACID; FATTY-ACIDS; RAT-LIVER; METABOLISM; INFLAMMATION; RESOLUTION; ENZYMES; CELLS;

D O I：

10.1016/j.bmc.2018.07.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

beta-Oxidation of most fatty acids occurs in the mitochondria. However, beta-oxidation for omega-3 polyunsaturated fatty acids (PUFAs) is distinct from abundant fatty acids and occurs in the peroxisomes. Since little is known about peroxisomal beta-oxidation, here we report the synthesis of proposed intermediates of omega-3 PUFA beta-oxidation steps in free fatty acid form having a conjugated double bond, a beta-hydroxyl group, a beta-olefin and a beta-carbonyl group. These fatty acids can serve as authentic samples for biological experiments.

引用

页码：4390 / 4401

页数：12

共 15 条

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